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STAT3 — TPO

Text-mined interactions from Literome

Yang et al., Blood 1999 : In addition, hG-CSF induced phosphorylation of STAT3 but not Jak2 or STAT5, while TPO induced phosphorylation of both
Wang et al., Blood 2000 : It was found that IFN-alpha directly suppresses TPO induced phosphorylation of the JAK2 substrates c-Mpl and STAT 5 in a TPO dependent hematopoietic cell line and of Mpl and STAT3 in primary murine MK
Kalina et al., Exp Hematol 2001 (Leukemia, Erythroblastic, Acute...) : Although STAT3 also was activated by TPO , STAT3 activation remained unaltered by TGF-beta1
Kirito et al., Blood 2002 : In addition, it was found that Stat3 activation induced by TPO stimulation was drastically suppressed in these Tg mice compared with littermates
Piu et al., Oncogene 2002 : Similarly, G-CSF and TPO lead to activation of STAT3 and STAT5 but, unlike the betac cytokine receptors, both stimulated cellular growth
Tong et al., J Exp Med 2004 : The absence of Lnk caused enhanced and prolonged Tpo induction of STAT3 , STAT5, Akt, and MAPK signaling pathways in CD41+ megakaryocytes
Segerer et al., Mol Hum Reprod 2013 : Studying the signalling pathway proteins in the uNK cells, an activation of STAT3/Tyr by TPO , was detected
Bacon et al., FEBS Lett 1995 (Leukemia, Megakaryoblastic, Acute) : Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3
Pallard et al., EMBO J 1995 (Leukemia, Megakaryoblastic, Acute) : We demonstrated that TPO activates the kinase JAK2 and a STAT5-like transcriptional factor but not STAT1, STAT2, STAT3 or STAT4, in a very rapid and transient manner
Matsumura et al., Mol Cell Biol 1997 (Leukemia, Megakaryoblastic, Acute) : Furthermore, we found that although TPO induced tyrosine phosphorylation of both STAT3 and STAT5 in CMK cells, only STAT5 showed binding activities to potential STAT binding sites that locate in the promoter region of p21 gene ( p21-SIE sites ), thereby leading to transactivation of p21
Miura et al., Acta Haematol 1998 (Leukemia...) : In UT-7/GM cells, EPO activated Stat5 alone, although the activation of Stat1 alpha, Stat3 , and Stat5 was induced by GM-CSF or TPO