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STAT3 — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lin et al., Cancer Res 2002
(Breast Neoplasms) :
We sought to determine whether there is functional
regulation of
Stat3 by wild-type ( wt )
p53 ... We demonstrate that expression of wt p53, but not mutant
p53 , significantly diminished phosphorylation of Stat3,
reduced Stat3 DNA binding activity, and inhibited Stat3 dependent transcriptional activity in breast cancer cells expressing constitutively active Stat3
Lin et al., Oncogene 2002
(Adenocarcinoma...) :
p53 regulates
Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3 ... We sought to investigate whether there is functional
regulation of
Stat3 by wild-type ( wt )
p53 ... Our results demonstrate that expression of wt
p53 but not mutant p53 significantly reduced tyrosine phosphorylation of Stat3 and
inhibited Stat3 DNA binding activity in both DU145 and Tsu prostate cancer cell lines that express constitutively active Stat3
Majumder et al., FEBS Lett 2003
(Cystitis...) :
HCV NS5A protein possesses many intriguing properties, including sequestration of
p53 in the cytoplasm, downregulation of p21 protein,
activation of
STAT3 , and inhibition of tumor necrosis factor-alpha mediated apoptosis
Niu et al., Mol Cell Biol 2005
(Neoplasms) :
Role of
Stat3 in regulating
p53 expression and function
Lee et al., Int J Cancer 2008
(Carcinoma, Squamous Cell...) :
Greater modulation among HNSCC lines expressing low wt p53 than those over expressing mt p53 protein suggested that decreased
p53 expression might
enhance activation of NF-kappaB,
STAT3 and BCL-XL
Hu et al., Mol Cancer Ther 2008
(Prostatic Neoplasms) :
Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces
p53 and
inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo
Noman et al., J Immunol 2009
(Anoxia...) :
Western blot analysis indicates that although hypoxia had no effect on
p53 accumulation, it
induced the phosphorylation of
STAT3 in tumor cells by a mechanism at least in part involving vascular endothelial growth factor secretion
Zhou et al., J Am Soc Nephrol 2010
(Disease Models, Animal...) :
AA induced dephosphorylation of
STAT3 and the subsequent
activation of
p53 and TEC apoptosis ... Taken together, these results suggest that AA induces TEC death via apoptosis by dephosphorylation of
STAT3 and posttranslational
activation of
p53 , supporting the hypothesis that p53 promotes renal injury in acute AAN
Choy et al., Genome medicine 2010
:
We further determined that
STAT3 was
necessary for the
p53-RELA complex to associate with this cis-element and for mir-21 expression
Park et al., Mol Carcinog 2012
(Colonic Neoplasms...) :
HFD feeding increased tumor tissue levels of Ki67, cyclin A, cyclin D1, CDK2, Bcl-xL, and Bcl-2 ; reduced
p53 levels and TUNEL positive apoptotic cells ; increased the levels of CD45, CD68, CD31, VEGF, P-VEGF receptor-2, iNOS, and COX-2 as well as hemoglobin content ; and
increased the levels of HIF-1a, P-STAT3-Y705,
P-STAT3-S727 , P-I?B-a, P-p65, p65, P-c-Jun, P-Akt, P-ERK1/2, P-p38, and P-SAPK/JNK
Seo et al., Mol Cell Biochem 2012
(Breast Neoplasms) :
Apigenin induces apoptosis via extrinsic pathway, inducing
p53 and
inhibiting STAT3 and NF?B signaling in HER2 overexpressing breast cancer cells