Gene interactions and pathways from curated databases and text-mining

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NOTCH4 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Laws et al., Eur J Immunol 2004 : We hypothesize that p53 regulates Notch activity during T cell development
Beverly et al., Cancer Res 2005 (Cell Transformation, Neoplastic...) : Therefore, it is the suppression of p53 that provides the Achilles heel for Notch induced tumors, as activation of p53 in the presence of Notch signaling drives tumor regression
Alimirah et al., Neoplasia (New York, N.Y.) 2007 (Neoplasms) : Notably, p53 differentially regulated the expression of Notch family members : expression of Notch2 and Notch4 was not induced by p53
Ban et al., Cancer Res 2008 (Sarcoma, Ewing) : EWS-FLI1 suppresses NOTCH activated p53 in Ewing 's sarcoma