Gene interactions and pathways from curated databases and text-mining

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PRKAR2A — TNFSF11

Text-mined interactions from Literome

Fujita et al., Prostaglandins Leukot Essent Fatty Acids 2003 : Investigation of intracellular signaling verified that low-density PGE ( 2 ) suppressed PKA activity in undifferentiated cells, suggesting that PGE ( 2 ) acts on the osteoclastic cell lineage to facilitate cell differentiation by suppressing PKA in the presence of RANKL
Nukaga et al., J Periodontol 2004 : The PGE2 stimulated RANKL expression was mediated by EP2/4 and cAMP dependent PKA , while PKC was possibly involved in the PGE2 action
Takami et al., FEBS Lett 2005 : Induction of TRANCE expression by IBMX was partially suppressed by the inhibitors of protein kinase A (PKA), ERK, and p38 MAPK, suggesting that activation of ERK and p38 MAPK, as well as PKA , is involved in TRANCE expression by IBMX
Bai et al., J Biol Chem 2005 (Bone Resorption) : In human MG63 cells, however, we found that ROS promoted heat shock factor 2 (HSF2) binding to heat shock element in human RANKL promoter region and that HSF2, but not PKA , was required for ROS up-regulation of RANKL as revealed by KT5720 and HSF2 RNA interference transfection
Kim et al., Mol Endocrinol 2007 : This study demonstrates that the activation of RankL gene expression by PKA- and gp130-inducers is mediated via common regulatory domains that also served to facilitate the activity of 1,25- ( OH ) 2D3