Gene interactions and pathways from curated databases and text-mining

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IL22 — TNFSF11

Text-mined interactions from Literome

Kim et al., Arthritis Rheum 2012 (Arthritis, Rheumatoid) : To examine the regulatory role of interleukin-22 (IL-22) in the expression of RANKL and induction of osteoclastogenesis in rheumatoid arthritis ( RA ) ... IL-22 induced RANKL expression was down-regulated significantly by the inhibition of p38 MAPK/NF-?B or JAK-2/STAT-3 signaling
Zheng et al., Biochem Pharmacol 2013 (Bone Resorption) : Coumermycin A1 also abrogated RANKL induced expression of interleukin-1ß , tumor necrosis factor-a, and inducible nitric oxide synthase in mouse BMMs. Consistent with the in vitro anti-osteoclastogenic effect, the aminocoumarin suppressed lipopolysaccharide induced osteoclast formation and bone loss in in vivo mouse experiments