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IL22 — TNFSF11
Text-mined interactions from Literome
Kim et al., Arthritis Rheum 2012
(Arthritis, Rheumatoid) :
To examine the regulatory
role of
interleukin-22 (IL-22) in the expression of
RANKL and induction of osteoclastogenesis in rheumatoid arthritis ( RA ) ...
IL-22 induced
RANKL expression was down-regulated significantly by the inhibition of p38 MAPK/NF-?B or JAK-2/STAT-3 signaling
Zheng et al., Biochem Pharmacol 2013
(Bone Resorption) :
Coumermycin A1 also abrogated
RANKL induced expression of
interleukin-1ß , tumor necrosis factor-a, and inducible nitric oxide synthase in mouse BMMs. Consistent with the in vitro anti-osteoclastogenic effect, the aminocoumarin suppressed lipopolysaccharide induced osteoclast formation and bone loss in in vivo mouse experiments