Gene interactions and pathways from curated databases and text-mining

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IGF1 — TNFSF11

Text-mined interactions from Literome

Rubin et al., J Clin Endocrinol Metab 2002 : Similarly, IGF-I at 100 micro g/liter ( 13 nM ) increased RANKL mRNA expression to 353 +/- 74 % above untreated cells as assessed by real-time PCR ... In summary, we conclude that IGF-I in a dose- and time dependent manner regulates OPG and RANKL in vitro and in vivo
Giannobile et al., J Periodontal Res 1996 (Periodontal Diseases) : The results from this study demonstrated that : 1 ) IGF-I alone at the dose tested did not significantly alter periodontal wound healing ; 2 ) PDGF-BB alone significantly stimulated NA, with trends of effect on other parameters ; and 3 ) the PDGF-BB/IGF-I combination resulted in significant increases in NA and ODF above vehicle at both 4 and 12 wk