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CHUK — TNFSF10
Pathways - manually collected, often from reviews:
-
NCI Pathway Database TRAIL signaling pathway:
TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Lin et al., Mol Cell Biol 2000, Harper et al., J Biol Chem 2001, Chaudhary et al., Immunity 1997
Evidence: mutant phenotype, reporter gene
-
NCI Pathway Database TRAIL signaling pathway:
TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Lin et al., Mol Cell Biol 2000, Harper et al., J Biol Chem 2001, Chaudhary et al., Immunity 1997
Evidence: mutant phenotype, assay, reporter gene
Text-mined interactions from Literome
Roué et al., J Immunol 2007
(Lymphoma, Mantle-Cell) :
These results present the combination of
TRAIL stimulation and
IkappaB kinase inhibition as a new approach to MCL therapy
Tanaka et al., Mol Cancer Res 2009
(Colonic Neoplasms...) :
PRMT5 contributed to
TRAIL induced activation of
inhibitor of kappaB kinase (IKK) and nuclear factor-kappaB (NF-kappaB), leading to induction of several NF-kappaB target genes
Seo et al., Exp Mol Med 2012
:
On the other hand, kurarinone significantly inhibited
TRAIL induced
IKK activation, I?B degradation and nuclear translocation of NF-?B, as well as effectively suppressed cellular FLICE-inhibitory protein long form ( cFLIPL ) expression