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AKT1 — TNFSF10

Text-mined interactions from Literome

Beresford et al., J Interferon Cytokine Res 2001 (Prostatic Neoplasms) : Suppression of PI3'-kinase/Akt signaling markedly enhanced the apoptotic activity of both TNF and TRAIL in LNCaP cells but not in PC-3 cells
Wang et al., J Biol Chem 2002 : Moreover, overexpression of active Akt , a downstream target of PI 3-kinase, or inhibition of GSK-3, a downstream target of active Akt, completely blocked the induction of TRAIL by wortmannin
Bild et al., Oncogene 2002 : MEKK1 induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage ... Thus, MEKK1 induced apoptosis requires TRAIL death receptor activation and is blocked by AKT through inhibition of MEKK1 cleavage
Milani et al., J Neurochem 2003 (Neuroblastoma) : TRAIL induced distinct short-term ( 1-60 min ) and long-term ( 3-24 h ) effects on the protein kinase B (PKB)/Akt ( Akt ), extracellular signal regulated kinase ( ERK ), cAMP response element binding protein ( CREB ), nuclear factor kappa B (NF-kappaB) and caspase pathways ... TRAIL induced distinct short-term ( 1-60 min ) and long-term ( 3-24 h ) effects on the protein kinase B (PKB)/Akt ( Akt ) , extracellular signal regulated kinase ( ERK ), cAMP response element binding protein ( CREB ), nuclear factor kappa B (NF-kappaB) and caspase pathways ... TRAIL rapidly ( from 20 min ) induced the phosphorylation of Akt and ERK, but not of c-Jun NH2-terminal kinase (JNK) ... Moreover, TRAIL increased CREB phosphorylation and phospho-CREB DNA binding activity in a phosphatidylinositol 3-kinase (PI 3K)/Akt dependent manner
Secchiero et al., Cell Mol Life Sci 2004 : Western blot analysis consistently showed that TRAIL induced a significant activation of ERK1/2, and a much weaker phosphorylation of Akt , while it did not affect the p38/MAPK pathway
Puduvalli et al., Apoptosis 2005 (Glioma) : Conversely, TRAIL induced caspase dependent cleavage of Akt neutralizing its anti-apoptotic effects
Okhrimenko et al., J Biol Chem 2005 (Glioma) : In addition, phosphorylation of PKCdelta on tyrosine 155 was necessary for the activation of AKT in response to TRAIL
Okhrimenko et al., Cancer Res 2005 (Glioma) : Similarly, TRAIL reduced the expression of AKT in glioma cells and this decrease was abolished in cells overexpressing PKCepsilon
Rieger et al., Cell Physiol Biochem 2007 (Glioma) : Apo2L.0 induced the phosphorylation of ERK1/2, but not of Akt
Lee et al., Am J Chin Med 2008 (Osteoarthritis) : Clematis mandshurica prevents Ad-TRAIL induced down-regulation of 14-3-3 and phosphorylated Akt
Song et al., Cell Signal 2010 : Data from gene knockdown experiments with an RNA interference ( RNAi ) technique show that c-Cbl is involved in the interaction between Src and PI3K p85 during TRAIL treatment, playing an important role in TRAIL induced Akt phosphorylation
Chen et al., Molecular cancer 2010 (Carcinoma, Non-Small-Cell Lung...) : The combination of GGTI-298 and TRAIL was more effective than each single agent in decreasing the levels of IkappaBalpha and p-Akt, implying that GGTI298/TRAIL activates NF-kappaB and inhibits Akt
Fujikawa et al., Clin Exp Rheumatol 2009 : TRAIL rapidly induced apoptosis of FLS as well as the phosphorylation of extracellular signal regulated kinase ( ERK ), p38, c-Jun N-terminal kinase (JNK) and Akt ... Notably, CaMKII chemical inhibitor abrogated TRAIL induced phosphorylation of Akt
Lane et al., Oncogene 2010 (Ascites...) : Ovarian cancer ascites protects from TRAIL induced cell death through alphavbeta5 integrin mediated focal adhesion kinase and Akt activation
Sun et al., Int J Oncol 2011 : TRAIL induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt ... Akt catalytic activation is known to increase during metabolic oxidative stress, but we show that TRAIL also dramatically induces the catalytic activation of Akt in TRAIL-sensitive cells, but not in TRAIL-resistant cells
Liu et al., Mol Med Report 2010 : Further investigation revealed that TRAIL engagement led to the activation of PI3K/Akt as well as of NF-?B ... Our data demonstrated that the activation of PI3K/Akt and NF-?B by TRAIL is responsible for resistance to TRAIL in human gastric cancer cells
Li et al., Thyroid 2013 (Thyroid Neoplasms) : Interestingly, while TRAIL induces a significant reduction in the levels of phospho-Akt ( pAkt ) and phospho-MADD ( pMADD ) in TRAIL-sensitive cells, it fails to do so in TRAIL-resistant cells
Zhang et al., J Biol Chem 2013 (Breast Neoplasms) : Mechanically, MTDH down-regulated caspase-8, decreased caspase-8 recruitment into the TRAIL death inducing signaling complex, decreased caspase-3 and poly(ADP-ribose) polymerase-2 processing, increased Bcl-2 expression, and stimulated TRAIL induced Akt phosphorylation, without altering death receptor status