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IGF1 — TNF
Text-mined interactions from Literome
Layne et al., Exp Cell Res 1999
:
In contrast,
TNF-alpha in the
presence or absence of 1 nM
IGF-I , did not stimulate DNA synthesis in myoblasts
Ballica et al., J Bone Miner Res 1999
:
CGRP inhibits osteoclasts, stimulates
insulin-like growth factor I and
inhibits tumor necrosis factor alpha production by osteoblasts in vitro
Onagbesan et al., J Reprod Fertil 2000
:
Effect of
TNF-alpha on LH and
IGF-I modulated chicken granulosa cell proliferation and progesterone production during follicular development
Gilbert et al., Endocrinology 2000
:
Northern analysis revealed that
TNF inhibited the expression of
insulin-like growth factor I (IGF-I)
Shalita-Chesner et al., Mol Cell Endocrinol 2001
:
This effect was associated with significant reductions in the levels of IGF-l-R mRNA and protein, and with inhibition of IGF-l-R promoter activity, suggesting that
TNF-alpha and IFN-gamma
affect IGF-l-R gene expression at the transcriptional level
Spicer et al., Anim Reprod Sci 2001
:
To further elucidate the role and mechanism of action of TNFalpha on ovarian cells, the effect of TNFalpha on
insulin-like growth factor-I (IGF-I) induced steroidogenesis and IGF-I binding sites in granulosa and thecal cells as well as the hormonal regulation of
TNFalpha receptors were evaluated
Spies et al., Gene Ther 2001
(Burns) :
Local
IGF-1 gene transfer
attenuates the mRNA expression of the inflammatory cytokines IL-1beta and
TNF-alpha in the burn wound
Palmieri et al., Am J Physiol Heart Circ Physiol 2002
:
After 20 min, whereas
TNF-alpha expression further increased, IL-6 and
IGF-1 levels progressively
reduced to values lower than those observed under moderate stretch and in unstretched ( 5 mmHg ) control myocardium ( IL-6 )
Ben et al., Zhonghua Shao Shang Za Zhi 2001
:
Additionally, rhGH ( at 40 ng/ml ) and
IGF-1 ( at all tested concentrations ) could
activate the secretion of
TNF and IL-6 from cultured mice Mphi in vitro
Anwar et al., Circulation 2002
(Arteriosclerosis) :
Tumor necrosis factor-alpha regulates
insulin-like growth factor-1 and insulin-like growth factor binding protein-3 expression in vascular smooth muscle ...
Tumor necrosis factor-alpha regulates insulin-like growth factor-1 and
insulin-like growth factor binding protein-3 expression in vascular smooth muscle ...
TNF-alpha , a cytokine that is upregulated in atherosclerotic plaques, reduces IGF-1 and increases IGFBP-3 in VSMCs, likely
leading to a reduction in bioactive
IGF-1
Garrouste et al., Cell Death Differ 2002
:
Correspondingly,
IGF-I markedly
enhanced the
TNF- and IFN/TNF induced NF-kappaB dependent interleukin-8 production
Ye et al., J Neurosci Res 2003
:
Recently
TNF-alpha has been shown to
inhibit IGF-I signaling and actions in non-neural tissue
Frost et al., Endocrinology 2003
:
The purpose of the present study was to determine whether LPS alters the expression of
TNF alpha and IGF-I in mouse skeletal muscle and whether TNF alpha directly
inhibits IGF-I mRNA expression in C2C12 myoblasts ...
TNF alpha completely
prevented GH-inducible
IGF-I mRNA expression, but this GH resistance was not attributable to impairment in signal transducer and activator of transcription-3 or -5 phosphorylation ... Yet inhibitor studies indicate that nitric oxide did not mediate the
effect of
TNF alpha on
IGF-I mRNA expression
Colson et al., J Endocrinol 2003
(Sepsis) :
Inhibition of
TNF-alpha production by pentoxifylline does not
prevent endotoxin induced decrease in serum
IGF-I ... The goal of our study was to investigate whether inhibition of
TNF-alpha production by pentoxifylline could
prevent the decrease in
IGF-I and the GH resistance caused by LPS injection
Liu et al., Pediatr Res 2003
:
Furthermore,
IGF-I inhibited apoptosis of CB DC and
increased the production of
tumor necrosis factor alpha (TNF-alpha) ... These effects are mediated through both MEK and PI 3-kinase pathways but not through the
IGF-I induction of
TNF-alpha production by the DC
Gao et al., Zhonghua Shao Shang Za Zhi 2004
(Burns) :
The plasma levels of PGE2, TXB2,
TNF-alpha and IL-6 significantly decreased and insulin, rhGH and
IGF-1 obviously
increased when compared with those in group B
Yuan et al., J Tradit Chin Med 2005
(Femur Head Necrosis) :
The serum
TNF-alpha decreased significantly and the
IGF-1 level
increased significantly in the Gufusheng group as compared with the model group ( both P < 0.01 )
Ahmed et al., Am J Physiol Gastrointest Liver Physiol 2006
:
TNF attenuated JAK2/STAT5 and ERK1/2 phosphorylation and
IGF-I and Spi 2.1 mRNA expression following GH stimulation
Wang et al., Am J Physiol Regul Integr Comp Physiol 2006
:
Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF, and
IGF-I in
response to
TNF by a p38 MAPK dependent mechanism ... We hypothesized that
tumor necrosis factor-alpha (TNF-alpha) stimulated progenitor cell secretion of vascular endothelial growth factor ( VEGF ), hepatocyte growth factor (HGF), and
insulin-like growth factor I (IGF-I) by a p38 mitogen activated protein kinase ( MAPK ) -dependent mechanism ... Secretion of VEGF, HGF, and
IGF-I in hMSCs and hAPCs was significantly
increased by stimulation with
TNF and was associated with increased activation of p38 MAPK ... The p38 MAPK inhibitor decreased production of
TNF stimulated VEGF, HGF, and
IGF-I in hMSCs and hAPCs
Hijikawa et al., Shock 2008
(Liver Failure) :
Insulin-like growth factor 1
inhibited increases in
TNF-alpha , IL-1 beta, and cytokine induced neutrophil chemoattractant 1 caused by GalN/LPS in serum and liver and enhanced serum IL-10
Kubota et al., Biochem Biophys Res Commun 2008
(Obesity) :
IGF-1 , but not GH,
inhibited the FFA induced TLR2 and
TNF-alpha expression in 3T3-L1 cells
Grounds et al., Clin Exp Pharmacol Physiol 2008
(Necrosis) :
3. Activation of
TNF signalling via the c-Jun N-terminal kinase (JNK) can
inhibit IGF-1 signalling by phosphorylation and conformational changes in insulin receptor substrate (IRS)-1 downstream of the IGF-1 receptor
Crisostomo et al., Am J Physiol Cell Physiol 2008
:
TNF-alpha , LPS, and hypoxia significantly
increased human MSC VEGF, FGF2, HGF, and
IGF-1 production versus controls
Moylan et al., Am J Physiol Cell Physiol 2008
:
TNF increases AKT phosphorylation ( +50 % ) and stimulation of AKT with
IGF does not
prevent TNF induction of atrogin mRNA
Buzzelli et al., Endocrinology 2008
:
TNF inhibits serine protease inhibitor 2.1 ( Spi 2.1 ) and
IGF-I gene expression by GH in CWSV-1 hepatocytes ... The 5- to 6-fold induction of Spi 2.1 and
IGF-I promoter activity by GH was
inhibited by
TNF ... IkappaBalphaS/A and IkappaBalphaTrunc ameliorated the inhibitory
effects of
TNF on GH-inducible Spi 2.1 and
IGF-I promoter activity ... Cycloheximide did not antagonize the inhibitory
effects of
TNF on GH-inducible
IGF-I expression
Hashimoto et al., Endocr J 2010
:
Tumor necrosis factor-alpha (TNF-alpha) inhibits
insulin-like growth factor-I (IGF-I) activities in human trophoblast cell cultures through IGF-I/insulin hybrid receptors
Chertoff et al., Exp Neurol 2011
(Chronic Disease...) :
Protective effects of low
TNF-a level could be
mediated by TNF-R1, GDNF, and
IGF-1 in the SN and SOD activity in the striatum ( ST )
Sukhanov et al., FEBS Lett 2011
(Atherosclerosis) :
On the contrary,
IGF-1 decreased oxidative stress and
suppressed TNF-a levels and these effects were blocked by l-NAME
Gude et al., Growth Horm IGF Res 2012
:
TNF-a reduced
IGF-I and IGF-II protein levels to 51±8 % and 69±8 %, respectively ( P=0.002 ), without affecting mRNA levels ... The secretion of
IGF-I is
affected by GH, IL-1ß and
TNF-a , whereas IGF-II is affected by TNF-a only
Gómez-Hernández et al., Endocrinology 2013
:
Thereby, IGF-II or
TNF-a induced IRA and IGF-I receptor (IGF-IR) overexpression as well as an increase of
IRA/IGF-IR hybrid receptors in VSMCs ... Finally, our data suggest that the IRA isoform and its association with TNF-R1 or
IGF-IR confers proliferative advantage to VSMCs, mainly in
response to
TNF-a or IGF-II, which might be of significance in the early atherosclerotic process
Bloch et al., Adv Enzyme Regul 1995
(Leukemia, Myeloid, Acute) :
In the absence of serum, ML-1 cells were found to
require IGF-1 and transferrin (TF) for growth and TGF-beta or
TNF-alpha plus TF for differentiation
Fournier et al., J Immunol 1995
:
Increased synthesis of
insulin-like growth factor I (IGF-I) , a fibroblast growth factor, is
induced in murine macrophages by
TNF-alpha ...
TNF-alpha did not
increase IGF-I synthesis by first inducing PGE2 synthesis, because indomethacin was unable to block the effect of TNF-alpha
Lazarus et al., Lymphokine Cytokine Res 1993
:
Insulin-like growth factor-1 activity is
inhibited by interleukin-1 alpha,
tumor necrosis factor-alpha , and interleukin-6
Noble et al., J Clin Invest 1993
(Fibrosis...) :
Furthermore,
IGF-1 induction was
dependent on endogenous
TNF alpha production since IGF-1 protein synthesis was inhibited in the presence of anti-TNF alpha antiserum ... These results indicate that hyaluronate activation of CD44 induces cytokine expression and macrophage derived
IGF-1 production is
dependent on
TNF alpha expression
Renier et al., Endocrinology 1996
:
Preexposure of macrophages with specific antibodies against IGF-I and IGF-I receptor before IGF-I addition resulted in a complete abrogation of the stimulatory effect of IGF-I on TNF alpha production, indicating that specific binding of IGF-I to its receptor is required for macrophage
TNF alpha induction by
IGF-I ... To assess the role of the tyrosine kinase system in mediating
IGF-I induced basal
TNF alpha production, macrophages were preincubated with the specific tyrosine kinase inhibitors, genistein and tyrphostin A9, before IGF-I exposure ... Addition of these compounds resulted in a dose dependent inhibition of the stimulatory effect of IGF-I on macrophage TNF alpha release, indicating that protein tyrosine kinase activation is required for
TNF alpha stimulation by
IGF-I
Urban et al., J Biol Chem 1996
:
IGF-I binding and IGF-I receptor mRNA concentrations in porcine granulosa cells were not
inhibited by
TNFalpha
Wolf et al., Eur J Endocrinol 1996
:
As many of the acute inflammatory responses in critical illness are mediated by the proinflammatory cytokines interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha), the present studies evaluated IL-1 beta and
TNF-alpha effects on steady-state and GH-stimulated
IGF-I synthesis and GH receptor mRNA levels ... In conclusion, we demonstrated that in rat hepatocytes in primary culture IL-1 beta and
TNF-alpha inhibited GH-stimulated
IGF-I synthesis
Thissen et al., Endocrinology 1997
:
To determine whether cytokines can directly inhibit the production of IGF-I by the liver, we investigated the
regulation of
IGF-I gene expression by interleukin (IL)-1 beta, IL-6, and
tumor necrosis factor (TNF)-alpha ( 10 ng/ml ) in a model of rat primary cultured hepatocytes ... IL-1 beta, and
TNF-alpha to a lesser extent, dramatically
inhibited the
IGF-I mRNA response to GH ( IL-1 beta : -82 %, P < 0.001 and TNF-alpha : -47 %, P < 0.01 )
Fournier et al., J Biol Chem 1997
:
Increased synthesis of
insulin-like growth factor-1 is
induced in murine macrophages by prostaglandin E2 ( PGE2 ) and
tumor necrosis factor-alpha (TNFalpha)
Lin et al., Mol Cell Endocrinol 1994
:
Recombinant murine
tumor necrosis factor-alpha inhibits cholesterol side-chain cleavage cytochrome P450 and
insulin-like growth factor-I gene expression in rat Leydig cells ... Finally, the
effect of
TNF-alpha on
IGF-I gene expression was investigated since IGF-I enhances Leydig cell androgen formation and IGF-I gene is expressed in high levels in Leydig cells
Qu et al., Metabolism 1998
(Protein Deficiency) :
Since insulin-like growth factor-I (IGF-I) is an important hormone regulator of intestinal proliferation, this study examined the
effects of dietary protein content and
tumor necrosis factor (TNF) on mRNA levels of
IGF-I , IGF-I receptor, IGF binding protein-3 (IGFBP-3), and IGFBP-4 and on the histology of the colon, jejunum, and ileum in protein malnourished rats ... However, in the jejunum and ileum, refeeding had no effect but
TNF caused a decrease in
IGF-I and IGFBP-3 mRNA levels in malnourished rats