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EPO — TNF
Text-mined interactions from Literome
Jelkmann et al., Exp Hematol 1999
:
Tumor necrosis factor p55 receptor ( TNF-RI )
mediates the in vitro inhibition of hepatic
erythropoietin production ... The present study was carried out to find out as to whether the 55 kD ( TNF-RI ) or the 75 kD ( TNF-RII ) receptor is responsible for the
TNFalpha induced inhibition of hepatic
Epo synthesis
Zhu et al., Zhonghua Xue Ye Xue Za Zhi 2000
(Anemia...) :
The
effects of
TNF alpha and IFN-gamma on cobalt induced
erythropoietin production in human hepatic cancer cells ( HepG2 ) were examined ...
TNF alpha and IFN-gamma could specifically
inhibit cobalt induced
Epo production in HepG2 cells, and suppressed normal bone marrow BFU-E and CFU-E growth in a dose dependent manner
Imagawa et al., FASEB J 2003
(Anemia) :
However, 15 U/ml IL-1beta, 220 U/ml
TNF-alpha , or 10 ( -3 ) M L-NMMA
inhibited Epo protein production and promoter activity, respectively ... Addition of 10 microM K-7174 rescued these inhibitions of
Epo protein production and promoter activity
induced by IL-1beta,
TNF-alpha , or L-NMMA, respectively
Zhai et al., Zhonghua Er Ke Za Zhi 2004
(Anemia...) :
This study aimed to detect the EPO levels in children 's ACD, to explore the relationship between EPO and tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) and, to evaluate the
effect of recombinant human
TNF alpha ( rhTNF-alpha ) on
EPO gene expression
Chen et al., Exp Cell Res 2004
:
Erythropoietin dependent autocrine secretion of
tumor necrosis factor-alpha in hematopoietic cells modulates proliferation via MAP kinase -- ERK-1/2 and does not require tyrosine docking sites in the EPO receptor ... The
EPO induced , membrane bound form of autocrine
TNF-alpha seemed to enhance proliferation of HCD57 and DA3-EPOR cells ; however, the concentration of secreted autocrine/paracrine TNF-alpha was never sufficient to have an effect ... BAF3 cells expressing a mutant EPOR with no cytoplasmic tyrosine residues were capable of triggering
EPO dependent
TNF-alpha synthesis and secretion, indicating that tyrosine docking sites in the EPOR were not required for EPO dependent TNF-alpha secretion
Lee et al., J Neurochem 2006
(Brain Edema...) :
In addition,
EPO reduced the mRNA level of
TNF-alpha , Fas and Fas-L, as well as the activities of caspase-8, 9 and 3
Fandrey et al., Ann N Y Acad Sci 1991
(Carcinoma, Hepatocellular...) :
Interleukin-1 and
tumor necrosis factor-alpha inhibit
erythropoietin production in vitro ... A dose dependent decrease of up to 60 % in
Epo production was
induced by interleukin-1 beta, interleukin-1 alpha, and
tumor necrosis factor-alpha ( in that order of potency )
Sasaki et al., Spine (Phila Pa 1976) 2011
(Intervertebral Disc Displacement...) :
Effects of
asialo-erythropoietin on pain related behavior and expression of phosphorylated-p38 map kinase and
tumor necrosis factor-alpha induced by application of autologous nucleus pulposus on nerve root in rat ...
A-EPO improved pain related behavior and
reduced the expression of p-p38 and
TNF-a
Cervellini et al., J Biol Regul Homeost Agents 2013
(Necrosis) :
Erythropoietin does not
affect TNF and IL-6 production directly
Makarova et al., Klin Med (Mosk) 2013
(Coronary Disease...) :
In most CHD patients elevated levels of
TNF-alpha inhibited hepatic synthesis of
EPO
Fandrey et al., Eur J Biochem 1994
(Carcinoma, Hepatocellular...) :
Hypoxia induced
erythropoietin (Epo) production in vitro is
suppressed by interleukin 1 beta (IL-1 beta),
tumor necrosis factor alpha (TNF) and phorbol esters
PiƩroni et al., Gerontology 1997
(Anemia...) :
These findings suggest that systemic
TNF alpha or IL-1 beta are not
involved in the
erythropoietin response to ACD