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TLR4 — TLR8

Text-mined interactions from Literome

Zhang et al., FEBS Lett 2002 : Co-expression of the alphav-TLR and beta5-TLR chimeras in 293T cells generated 10 TLR homodimers, but only TLR4/4 could effectively activate NF-kappaB
Cabral et al., J Infect Dis 2006 : TLR4 stimulation had no effect on TLR2, TLR1 , and TLR5 expression
Mueller et al., J Immunol 2006 : TLR4/MD-2 mediated LPS uptake and TLR ligand induced I-kappaBalpha phosphorylation and IL-8 secretion were significantly diminished in Th2 cytokine primed IECs
Furuta et al., Eur J Immunol 2008 (Malaria) : Innate immune responses to PbAPrx were examined using cells from mice deficient in Toll-like receptors ( TLR ) or related molecules, and it was demonstrated that responses were severely impaired in TLR4 ( -/- ), MyD88 ( -/- ) and MD-2 ( -/- ) mice, but not in Toll/IL-1 receptor domain containing adaptor inducing IFN-gamma ( TRIF ) ( -/- ), TLR2 ( -/- ) or radioprotective 105 ( RP105 ) ( -/- ) mice
Kimman et al., PloS one 2008 : Activation of the Toll-like receptor ( TLR ) signaling pathway through TLR4 may be important in the induction of protective immunity against Bordetella pertussis with TLR4 mediated activation of dendritic and B cells, induction of cytokine expression, and reversal of tolerance as crucial steps
Regueiro et al., Infect Immun 2009 : We showed that Klebsiella induced TLR2 and TLR4 upregulation was dependent on TLR activation
Messlik et al., J Proteome Res 2009 (Chronic Disease...) : The aim of this study was to characterize the role of TLR2 or TLR4 deficiency in epithelial cell stress responses under noninflamed and inflamed conditions using TLR-deficient mice and TLR ( -/- ) cross bred IL-10-deficient mice as a model for genetically driven experimental colitis
van Bruggen et al., J Innate Immun 2010 (Bacterial Infections...) : Surprisingly, the reactivity towards certain established TLR ligands, imiquimod and ODN-CpG, was unaffected by IRAK-4 deficiency, demonstrating their activity is independent of TLR. TLR-4 dependent signaling in neutrophils was totally dependent on IRAK-4 without any major TRIF mediated contribution
Yang et al., J Exp Clin Cancer Res 2010 (Breast Neoplasms) : TLR4AsiRNA, TLR4BsiRNA and TLR4CsiRNA were found to significantly inhibit TLR4 expression in MDA-MB-231 at both mRNA and protein levels as compared to vector control ( vector transfected cells )
Kim et al., FEMS Microbiol Lett 2012 (Inflammation) : L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of toll-like receptor (TLR) 2, TLR4 , and TLR9 and the induction of interleukin-1 receptor associated kinase M, a negative regulator of TLR
Jia et al., Shanghai Kou Qiang Yi Xue 2011 : CD14, TLR4 receptors are involved in P.e-LPS effect and CD14, TLR2 and TLR4 receptors are involved in P.g-LPS effect in mouse osteoblast
Raicevic et al., Tissue Eng Part A 2012 : Inflammation was mimicked by a cytokine cocktail, and TLR activation was induced through TLR3 and TLR4 ligation
Neal et al., J Biol Chem 2012 (Enterocolitis, Necrotizing) : To define molecular mechanisms involved, TLR4 inhibited ISC proliferation and increased apoptosis via the p53-up regulated modulator of apoptosis ( PUMA ), as TLR4 did not affect crypt proliferation or apoptosis in organoids or mice lacking PUMA
Deng et al., Immunol Cell Biol 2013 : The TLR signals that regulate the phagocytic ability of macrophages were also induced by TLR4 and TLR5 activation
Ciechomska et al., Ann Rheum Dis 2013 (Arthritis, Rheumatoid...) : This study demonstrates profibrotic properties of circulating monocytes from patients with SSc and a key role for TLR signalling, particularly TLR8 , in TIMP-1 secretion and matrix remodelling