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STAT3 — TLR2

Text-mined interactions from Literome

Fukuzono et al., Arch Biochem Biophys 2010 : G-CSF mediated STAT3 phosphorylation and inhibition of TLR agonist induced cytokine production were prevented by pretreatment of cells with AG-490 ( JAK2 inhibitor )
Tel et al., Cancer Immunol Immunother 2012 : Furthermore, oxaliplatin decreased TLR induced STAT1 and STAT3 expression, and NF-?B mediated responses
Ochi et al., J Clin Invest 2012 (Carcinoma, Pancreatic Ductal...) : Furthermore, TLR7 ligation induced STAT3 activation and interfaced with Notch as well as canonical NF-?B and MAP kinase pathways, but downregulated expression of Notch target genes
Tye et al., Cancer Cell 2012 (Cell Transformation, Neoplastic...) : Using a GC mouse model driven by hyperactivation of the signal transducer and activator of transcription ( STAT ) 3 oncogene, we show that STAT3 directly upregulates the epithelial expression of the inflammatory mediator Toll-like receptor (TLR)2 in gastric tumors
Melkamu et al., Journal of cell communication and signaling 2013 : TLR3 activation evokes IL-6 secretion, autocrine regulation of Stat3 signaling and TLR2 expression in human bronchial epithelial cells ... TLR2 up-regulation by poly I:C was also reduced by IL-6Ra-nAb and inhibitors of Jak2, Stat3 and NF-?B phosphorylation, whereas RANTES secretion was unaffected, but abolished following NF-?B inhibition ... The results also indicate that NF-?B and Stat3 are required for TLR3 dependent up-regulation of TLR2 and that its delayed expression was due to a requirement for IL-6 dependent Stat3 activation