Gene interactions and pathways from curated databases and text-mining

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CHUK — TLR2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Wang et al., Infect Immun 2001 : These data indicate that micrococci and PGN induce TLR2 dependent activation of the gene for IL-8 and that this activation requires MyD88, IRAK, NIK, IKK , and NF-kappaB and may also utilize TRAF6 and, to a lesser extent, TRAF2
Chiu et al., Chem Biol Interact 2009 : Propofol inhibits lipoteichoic acid induced iNOS gene expression in macrophages possibly through downregulation of toll-like receptor 2-mediated activation of Raf-MEK1/2-ERK1/2-IKK-NFkappaB
Tong et al., Cell Res 2012 : NLRC5 ablation reduces MHC class I expression, and enhances IKK and IRF3 phosphorylation in response to TLR stimulation or viral infection