Gene interactions and pathways from curated databases and text-mining

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AKT1 — TLR2

Text-mined interactions from Literome

Miller et al., Arterioscler Thromb Vasc Biol 2005 (Atherosclerosis) : In turn, TLR4 regulated phosphorylation of ERK1/2 but not of Akt , suggesting that mmLDL induced PI3K activation is TLR4 independent
Lentschat et al., J Immunol 2005 : In addition to inhibition of TLR4 mediated MAPK phosphorylation in macrophages, mastoparan blunted IL-1R associated kinase-1 kinase activity induced by LPS, but not by TLR2 agonists, yet failed to affect phosphorylation of Akt by phosphoinositol-3-kinase induced by either TLR2- or TLR4 mediated signaling
Yang et al., Cell Microbiol 2006 (MAP Kinase Signaling System) : To extend these studies, we examined the nature of the involvement of toll-like receptors ( TLRs ) and intracellular signalling pathways downstream from PI3K in M. tbc induced IL-23 expression in human MDMs. M. tbc induced Akt activation and IL-23 expression were essentially dependent on TLR2
Pathak et al., Nat Immunol 2007 : Direct binding of ESAT-6 to TLR2 activated Akt and prevented interaction between the adaptor MyD88 and ` downstream ' kinase IRAK4, thus abrogating NF-kappaB activation
Quigley et al., Blood 2009 (Vaccinia) : Furthermore, we observed that direct TLR2 ligation on CD8 T cells promoted CD8 T-cell proliferation and survival in vitro in a manner dependent on the phosphatidylinositol 3-kinase (PI3K)-Akt pathway activation and that activation of Akt controlled memory cell formation in vivo
Santos-Sierra et al., EMBO J 2009 : In contrast to TLR2/6, TLR2/1 does not require Mal or MyD88 for Akt phosphorylation ... In contrast to TLR2/6, TLR2/1 does not require Mal or MyD88 for Akt phosphorylation
Wagner et al., Arterioscler Thromb Vasc Biol 2013 (Ischemia...) : The effects of anti-TLR2 ABs were similar to those exerted by stromal cell derived factor-1, and we show that anti-TLR2 ABs yet not TLR2 ligands lead to comparable activation of extracellular signal regulated kinase1/2 and AKT but not p38 mitogen activated protein kinase as activation of the CXCR4 canonical signal transduction pathways by stromal cell derived factor-1