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TLR10 — TLR4
Text-mined interactions from Literome
Zhang et al., FEBS Lett 2002
:
Co-expression of the alphav-TLR and beta5-TLR chimeras in 293T cells generated 10
TLR homodimers, but only
TLR4/4 could effectively
activate NF-kappaB
Cabral et al., J Infect Dis 2006
:
TLR4 stimulation
had no effect on TLR2,
TLR1 , and TLR5 expression
Mueller et al., J Immunol 2006
:
TLR4/MD-2 mediated LPS uptake and
TLR ligand induced I-kappaBalpha phosphorylation and IL-8 secretion were significantly diminished in Th2 cytokine primed IECs
Furuta et al., Eur J Immunol 2008
(Malaria) :
Innate immune responses to PbAPrx were examined using cells from mice deficient in Toll-like receptors ( TLR ) or related molecules, and it was demonstrated that responses were severely impaired in
TLR4 ( -/- ), MyD88 ( -/- ) and MD-2 ( -/- ) mice, but not in Toll/IL-1 receptor domain containing adaptor
inducing IFN-gamma ( TRIF ) ( -/- ),
TLR2 ( -/- ) or radioprotective 105 ( RP105 ) ( -/- ) mice
Kimman et al., PloS one 2008
:
Activation of the
Toll-like receptor ( TLR ) signaling pathway through
TLR4 may be important in the induction of protective immunity against Bordetella pertussis with TLR4 mediated activation of dendritic and B cells, induction of cytokine expression, and reversal of tolerance as crucial steps
Regueiro et al., Infect Immun 2009
:
We showed that Klebsiella induced TLR2 and
TLR4 upregulation was
dependent on
TLR activation
Messlik et al., J Proteome Res 2009
(Chronic Disease...) :
The aim of this study was to characterize the
role of TLR2 or
TLR4 deficiency in epithelial cell stress responses under noninflamed and inflamed conditions using TLR-deficient mice and
TLR ( -/- ) cross bred IL-10-deficient mice as a model for genetically driven experimental colitis
van Bruggen et al., J Innate Immun 2010
(Bacterial Infections...) :
Surprisingly, the reactivity towards certain established TLR ligands, imiquimod and ODN-CpG, was unaffected by IRAK-4 deficiency, demonstrating their activity is independent of
TLR. TLR-4 dependent signaling in neutrophils was totally dependent on IRAK-4 without any major TRIF mediated contribution
Yang et al., J Exp Clin Cancer Res 2010
(Breast Neoplasms) :
TLR4AsiRNA,
TLR4BsiRNA and TLR4CsiRNA were found to significantly
inhibit TLR4 expression in MDA-MB-231 at both mRNA and protein levels as compared to vector control ( vector transfected cells )
Kim et al., FEMS Microbiol Lett 2012
(Inflammation) :
L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of toll-like receptor (TLR) 2,
TLR4 , and TLR9 and the induction of interleukin-1 receptor associated kinase M, a negative
regulator of
TLR
Jia et al., Shanghai Kou Qiang Yi Xue 2011
:
CD14,
TLR4 receptors are involved in P.e-LPS effect and CD14,
TLR2 and TLR4 receptors are
involved in P.g-LPS effect in mouse osteoblast
Raicevic et al., Tissue Eng Part A 2012
:
Inflammation was mimicked by a cytokine cocktail, and
TLR activation was
induced through TLR3 and
TLR4 ligation
Neal et al., J Biol Chem 2012
(Enterocolitis, Necrotizing) :
To define molecular mechanisms involved,
TLR4 inhibited ISC proliferation and increased apoptosis via the p53-up regulated modulator of apoptosis ( PUMA ), as
TLR4 did not
affect crypt proliferation or apoptosis in organoids or mice lacking PUMA
Deng et al., Immunol Cell Biol 2013
:
The
TLR signals that regulate the phagocytic ability of macrophages were also
induced by
TLR4 and TLR5 activation