Gene interactions and pathways from curated databases and text-mining

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TLR1 — TLR4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Spitzer et al., Eur J Immunol 2002 : Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells
Zhang et al., FEBS Lett 2002 : Co-expression of the alphav-TLR and beta5-TLR chimeras in 293T cells generated 10 TLR homodimers, but only TLR4/4 could effectively activate NF-kappaB
Cabral et al., J Infect Dis 2006 : TLR4 stimulation had no effect on TLR2, TLR1 , and TLR5 expression
Mueller et al., J Immunol 2006 : TLR4/MD-2 mediated LPS uptake and TLR ligand induced I-kappaBalpha phosphorylation and IL-8 secretion were significantly diminished in Th2 cytokine primed IECs
Furuta et al., Eur J Immunol 2008 (Malaria) : Innate immune responses to PbAPrx were examined using cells from mice deficient in Toll-like receptors ( TLR ) or related molecules, and it was demonstrated that responses were severely impaired in TLR4 ( -/- ), MyD88 ( -/- ) and MD-2 ( -/- ) mice, but not in Toll/IL-1 receptor domain containing adaptor inducing IFN-gamma ( TRIF ) ( -/- ), TLR2 ( -/- ) or radioprotective 105 ( RP105 ) ( -/- ) mice
Kimman et al., PloS one 2008 : Activation of the Toll-like receptor ( TLR ) signaling pathway through TLR4 may be important in the induction of protective immunity against Bordetella pertussis with TLR4 mediated activation of dendritic and B cells, induction of cytokine expression, and reversal of tolerance as crucial steps
Regueiro et al., Infect Immun 2009 : We showed that Klebsiella induced TLR2 and TLR4 upregulation was dependent on TLR activation
Kidd et al., Neurogastroenterol Motil 2009 (Crohn Disease) : Interleukins ( IL1beta ) and bacterial products ( E. coli LPS ) stimulated 5HT secretion from Crohn 's EC cells via TIL receptor activation ( TLR4 and IL1beta )
Bayas et al., Clin Exp Immunol 2009 (Bacterial Infections...) : In peripheral blood mononuclear cells, TLR-9 stimulation with type A CpG ODN resulted in a higher expression of TLR-1 , -2, -4, -5 and -8 in MS patients ( n = 7 ) compared with healthy controls ( n = 11 )
Messlik et al., J Proteome Res 2009 (Chronic Disease...) : The aim of this study was to characterize the role of TLR2 or TLR4 deficiency in epithelial cell stress responses under noninflamed and inflamed conditions using TLR-deficient mice and TLR ( -/- ) cross bred IL-10-deficient mice as a model for genetically driven experimental colitis
van Bruggen et al., J Innate Immun 2010 (Bacterial Infections...) : Surprisingly, the reactivity towards certain established TLR ligands, imiquimod and ODN-CpG, was unaffected by IRAK-4 deficiency, demonstrating their activity is independent of TLR. TLR-4 dependent signaling in neutrophils was totally dependent on IRAK-4 without any major TRIF mediated contribution
Goethals et al., Glia 2010 (Wallerian Degeneration) : Upon axotomy, TLR1 becomes strongly induced , while most other TLR expression levels remain unaffected
Yang et al., J Exp Clin Cancer Res 2010 (Breast Neoplasms) : TLR4AsiRNA, TLR4BsiRNA and TLR4CsiRNA were found to significantly inhibit TLR4 expression in MDA-MB-231 at both mRNA and protein levels as compared to vector control ( vector transfected cells )
Yang et al., Bing Du Xue Bao 2011 (Marek Disease...) : By comparing the TLRs transcription between YL040920 and CVI988/Rispens infected microglia, it was suggested that vvMDV YL040920 might induce more TLR15 transcript than the attenuated vaccine strain CVI988/Rispens ( P < or = 0.01/0.001 ), while CVI988/Rispens induced more TLR1LB transcript than YL040920 ( P < or = 0.001 )
Kim et al., FEMS Microbiol Lett 2012 (Inflammation) : L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of toll-like receptor (TLR) 2, TLR4 , and TLR9 and the induction of interleukin-1 receptor associated kinase M, a negative regulator of TLR
Jia et al., Shanghai Kou Qiang Yi Xue 2011 : CD14, TLR4 receptors are involved in P.e-LPS effect and CD14, TLR2 and TLR4 receptors are involved in P.g-LPS effect in mouse osteoblast
Raicevic et al., Tissue Eng Part A 2012 : Inflammation was mimicked by a cytokine cocktail, and TLR activation was induced through TLR3 and TLR4 ligation
Neal et al., J Biol Chem 2012 (Enterocolitis, Necrotizing) : To define molecular mechanisms involved, TLR4 inhibited ISC proliferation and increased apoptosis via the p53-up regulated modulator of apoptosis ( PUMA ), as TLR4 did not affect crypt proliferation or apoptosis in organoids or mice lacking PUMA
Deng et al., Immunol Cell Biol 2013 : The TLR signals that regulate the phagocytic ability of macrophages were also induced by TLR4 and TLR5 activation