◀ Back to AKT1
AKT1 — TIMP2
Text-mined interactions from Literome
Wang et al., Cell Signal 2005
(MAP Kinase Signaling System...) :
Differential activation of the MEK/ERK and PI3K/AKT pathways that result in differential secretion IL-6, IL-8, TIMP-2 and VEGF were seen contingent on the cell type examined ; VEGF and
TIMP-2 expression in PC3 cells are
dependent on
AKT activation and ERK activation in LNCaP and LNCaP C4-2B cells leads to IL-6 or IL-8 secretion
Lee et al., Lab Invest 2010
:
Our results show that
Ala+TIMP-2 selectively alters the phosphorylation pattern of VEGFR-2 after VEGF-A stimulation and
disrupts the downstream activation of PLC-gamma, Ca(+2) flux,
Akt , and eNOS, as well as decreasing cGMP levels
Li et al., Phytomedicine 2010
(Hyperplasia) :
Furthermore, the augmented expression of CTGF and
TIMP-2 in HG-exposed cells was
mediated by
Akt activation and TGF-beta/Smad signaling through PKCbeta2-responsive signaling pathways