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STAT3 — TIMP1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Liu et al., Zhonghua Yi Xue Za Zhi 2001
:
STAT1 and
STAT3 antisense oligonucleotides
inhibited both STAT DNA binding activity and
TIMP1 mRNA expression in mesangial cells
Chen et al., Kidney Int 2002
:
STAT1 and
STAT3 mediate thrombin induced expression of
TIMP-1 in human glomerular mesangial cells ... EMSA showed that STAT1 and
STAT3 antisense oligonucleotides could
inhibit both thrombin induced STAT-DNA binding activities and
TIMP-1 mRNA expression ; the supershift assay showed that the SIF band consisted of STAT1 and STAT3 proteins ... Both STAT1 and
STAT3 may be
involved , at least in part, in thrombin induced expression of the
TIMP-1 gene in cultured human mesangial cells
Chen et al., Kidney Int 2003
:
Northern and Western blots showed that STAT1 and
STAT3 antisense oligonucleotides could
inhibit angiotensin II-induced
TIMP-1 expressions, and STAT1 and STAT3 proteins, respectively, could be supershifted by their polyclonal antibodies ... STAT1 and
STAT3 may, at least in part,
mediate angiotensin II-induced
TIMP-1 mRNA expression in human renal proximal tubular epithelial cells, implicating a role of the STAT signaling pathway in pathogenesis of renal tubulointerstitial fibrosis
Lai et al., Am J Pathol 2004
(Lymphoma, Large B-Cell, Diffuse) :
Specific inhibition of
STAT3 with a dominant negative construct
led to concentration dependent down-regulation of
TIMP1 expression in two anaplastic lymphoma kinase (ALK) ( + ) ALCL cell lines, Karpas 299 and SU-DHL-1 ... In conclusion,
STAT3 directly
contributes to the high level of
TIMP1 expression in ALK ( + ) ALCL, and TIMP1 expression correlates with high level of STAT3 activation in ALCL