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CHUK — TIFA
Text-mined interactions from Literome
Ea et al., Proc Natl Acad Sci U S A 2004
:
TIFA activates
IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6 ... Here, we present evidence that
TIFA ( TRAF interacting protein with a forkhead associated domain, also known as T2BP )
activates IKK by promoting the oligomerization and Ub ligase activity of TRAF6 ... Furthermore,
TIFA activates
IKK in an in vitro reconstitution system consisting of purified proteins, including TRAF6, the TAK1 kinase complex, and Ub-conjugating enzyme complex Ubc13-Uev1A ... Interestingly, a fraction of recombinant TIFA protein exists as high-molecular-weight oligomers, and only these oligomeric forms of
TIFA can
activate IKK
Minoda et al., Biochem Biophys Res Commun 2006
:
TIFA ( TRAF interacting protein with a forkhead associated ( FHA ) domain ) has been shown to bind to TRAF6 and
activate IKK by promoting the oligomerization and ubiquitin-ligase activity of TRAF6