Gene interactions and pathways from curated databases and text-mining

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CHUK — TIFA

Text-mined interactions from Literome

Ea et al., Proc Natl Acad Sci U S A 2004 : TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6 ... Here, we present evidence that TIFA ( TRAF interacting protein with a forkhead associated domain, also known as T2BP ) activates IKK by promoting the oligomerization and Ub ligase activity of TRAF6 ... Furthermore, TIFA activates IKK in an in vitro reconstitution system consisting of purified proteins, including TRAF6, the TAK1 kinase complex, and Ub-conjugating enzyme complex Ubc13-Uev1A ... Interestingly, a fraction of recombinant TIFA protein exists as high-molecular-weight oligomers, and only these oligomeric forms of TIFA can activate IKK
Minoda et al., Biochem Biophys Res Commun 2006 : TIFA ( TRAF interacting protein with a forkhead associated ( FHA ) domain ) has been shown to bind to TRAF6 and activate IKK by promoting the oligomerization and ubiquitin-ligase activity of TRAF6