Gene interactions and pathways from curated databases and text-mining

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MAPK6 — TIE1

Text-mined interactions from Literome

Yoon et al., Biochem Biophys Res Commun 2003 : Our results indicate that : ( 1 ) caveolae may be the platform for Tie2/PLD association in endothelial cells ; ( 2 ) PLD is a new mediator of Ang1/Tie2 induced signaling pathway, and it participates in MAPK activation and endothelial cell migration
Yuan et al., FASEB J 2007 : Ang1 mediated AKT and 42/44MAPK phosphorylation is predominantly Tie2 mediated , and Tie1 down-regulates this pathway
Samuel et al., Diabetes 2010 (Diabetes Mellitus, Experimental...) : We also observed increased phosphorylated mitogen activated protein kinase activated protein kinase-2, 2 days after the treatment and increased expression of vascular endothelial growth factor ( VEGF ), Flk-1, angiopoietin-1 (Ang-1), Tie-2 , and survivin, 4 days after treatment in the diabetic animals