Gene interactions and pathways from curated databases and text-mining

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MAPK6 — TGFB3

Text-mined interactions from Literome

Johansson et al., J Cell Sci 2000 (Carcinoma, Squamous Cell) : In addition, transforming growth factor- ( beta ) ( TGF- ( beta ) activated p38 MAPK in both cell lines, and ERK2 in A-5 cells
Lu et al., Endocrinology 2001 : In addition, PKC and MAPK inhibitors had no effect on the induction of TGFbeta3 promoter activity by the SERM EM-652 ... These results indicate that induction of the TGFbeta3 promoter by the E(2)/ERalpha complex requires the concomitant activation of PKC and MAPK signaling and provide a novel framework for the design of more effective estrogen based therapeutic strategies
Westermarck et al., Mol Cell Biol 2001 (MAP Kinase Signaling System) : In contrast, activation of stress activated c-Jun N-terminal kinase and p38 pathways by expression of constitutively active mutants of Rac, transforming growth factor beta activated kinase 1 ( TAK1 ), MAPK kinase 3 ( MKK3 ) , or MKK6 or by treatment with arsenite or anisomycin did not alone markedly enhance MMP-1 promoter activity
Bhowmick et al., J Biol Chem 2001 : Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity
Sato et al., J Invest Dermatol 2002 (Scleroderma, Systemic) : Role of p38 MAPK in transforming growth factor beta stimulation of collagen production by scleroderma and healthy dermal fibroblasts ... In conclusion, this study demonstrates a costimulatory role for p38 MAPK in transforming growth factor beta induction of the collagen type I gene
Suzuki et al., Clin Exp Nephrol 2004 : Role of mitogen activated protein kinase in the regulation of transforming growth factor-beta induced fibronectin accumulation in cultured renal interstitial fibroblasts
Roux et al., J Biol Chem 2005 (Edema) : The inhibitory effect of IL-1beta on alpha ENaC expression was mediated by the activation of p38 MAPK in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta
Leung et al., Nephrol Dial Transplant 2005 : The GDP induced VEGF and transforming growth factor ( TGF ) -beta synthesis in HPMC was partially reduced by either the p42/p44 MAPK inhibitor ( PD98059 ) or the PKC inhibitor ( staurosporine )
Chaturvedi et al., J Pharmacol Exp Ther 2005 (MAP Kinase Signaling System) : Pretreatment of FS cells with a mitogen activated protein kinase kinase 1/2 inhibitor or with a protein kinase C ( PKC ) inhibitor suppressed the TGF-beta3 and ethanol actions on MAPK p44/42 activation and bFGF release ... Furthermore, the MAPK p44/42 activation by TGF-beta3 and ethanol was blocked by overexpression of Ras N17, a dominant negative mutant of Ras p21
Gaide Chevronnay et al., Endocrinology 2008 : In presence of ovarian steroids, MAPK inhibitors ( p38 and ERK pathways ) stimulated TGF-beta3 but inhibited TGF-beta2 expression ... The opposite regulation of TGF-beta2 and -beta3 by cAMP and MAPK could account for their distinct expression in vivo
Krug et al., Hypertension 2010 : MR blockade and extracellular signal regulated kinase 1/2 mitogen activated protein kinase inhibition prevent age associated increases of transforming growth factor-beta , intercellular adhesion molecule 1, and procollagen 1
Leenders et al., J Biol Chem 2010 (Hypertrophy, Left Ventricular) : We show that transforming growth factor-beta mediated activation of p38 MAPK is necessary and sufficient to decrease KLF15 expression