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MAPK6 — TGFB1

Text-mined interactions from Literome

Han et al., J Biol Chem 2000 : TGF-beta1/TGF-beta2 increased phosphorylation of both mitogen activated protein ( MAP ) kinase and PPAR-gamma, whereas MAP kinase inhibitors reversed suppression of CD36 and inhibited PPAR-gamma phosphorylation induced by TGF-beta1/TGF-beta2
Johansson et al., J Cell Sci 2000 (Carcinoma, Squamous Cell) : In addition, transforming growth factor- ( beta ) ( TGF- ( beta ) activated p38 MAPK in both cell lines, and ERK2 in A-5 cells
Gruden et al., Diabetes 2000 : Mechanical stretch induced fibronectin and transforming growth factor-beta1 production in human mesangial cells is p38 mitogen activated protein kinase dependent
Junn et al., J Immunol 2000 : In addition, TGF-beta1 or H2O2 increased MAPK activity which was reduced by EGTA and NAC, suggesting that MAPK is involved in TGF-beta1 induced IL-6 expression
Brunetti et al., Thromb Haemost 2000 : In conclusion, we report for the first time that PMN apoptosis is potently inhibited by platelet released mediators, that TGF-beta1 mediates an important part of this effect, and that p38 MAPK is involved in the TGF-beta1 signaling leading to its anti-apoptotic effect
Chin et al., American journal of physiology. Renal physiology 2001 : TGF-beta(1) rapidly induced p38 MAPK phosphorylation in wild-type and empty vector ( pcDNA3 ) -transfected control mesangial cells ... Interestingly, transfection with dominant negative TbetaR-II ( M ) failed to block TGF-beta(1) induced p38 MAPK phosphorylation
Hashimoto et al., Am J Respir Crit Care Med 2001 : The results showed that : ( 1 ) TGF-beta1 caused the phenotypic modulation of HLF to myofibroblasts in a dose- and a time dependent manner ; ( 2 ) TGF-beta1 induced increases in c-Jun-NH2- terminal kinase (JNK), p38 MAPK, and extracellular signal regulated kinase ( Erk ) phosphorylation and activity ; ( 3 ) the inhibitors CEP-1347, SB 203580, and PD 98059 attenuated TGF-beta1 induced JNK, p38 MAPK , and Erk activity, respectively ; and ( 4 ) CEP-1347, but not SB 203580 or PD 98059, attenuated the TGF-beta1 induced phenotypic modulation of HLF to myofibroblasts in a dose dependent manner
Westermarck et al., Mol Cell Biol 2001 (MAP Kinase Signaling System) : In contrast, activation of stress activated c-Jun N-terminal kinase and p38 pathways by expression of constitutively active mutants of Rac, transforming growth factor beta activated kinase 1 ( TAK1 ), MAPK kinase 3 ( MKK3 ) , or MKK6 or by treatment with arsenite or anisomycin did not alone markedly enhance MMP-1 promoter activity
Bhowmick et al., J Biol Chem 2001 : Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity
Baxter et al., J Cardiovasc Pharmacol 2001 (Myocardial Infarction...) : Cardioprotective effects of transforming growth factor-beta1 during early reoxygenation or reperfusion are mediated by p42/p44 MAPK ... TGF-beta1 activated p42/p44 MAPK transiently in normoxic myocytes
Goldberg et al., Am J Physiol Lung Cell Mol Physiol 2002 : p38 MAPK activation by TGF-beta1 increases MLC phosphorylation and endothelial monolayer permeability
Sato et al., J Invest Dermatol 2002 (Scleroderma, Systemic) : Role of p38 MAPK in transforming growth factor beta stimulation of collagen production by scleroderma and healthy dermal fibroblasts ... In conclusion, this study demonstrates a costimulatory role for p38 MAPK in transforming growth factor beta induction of the collagen type I gene
Weigert et al., Diabetologia 2002 (Hyperglycemia) : Co-incubation with ang II and high glucose had no additive effect on TGF-beta 1 promoter activity, protein binding to the AP-1 box B or activation of p38 MAPK
Hyman et al., Surgery 2002 (MAP Kinase Signaling System) : We hypothesized that TGF-beta1 activates endothelial cell MAPKs and induces apoptosis through p38 ( MAPK ) activation ... TGF-beta1 induced p38 ( MAPK ), extracellular signal regulated kinase 1/2, and c-Jun N-terminal kinase 1/2 activation and increased apoptosis ... TGF-beta1 induces endothelial cell apoptosis through p38 ( MAPK ) activation
Cao et al., Am J Physiol Gastrointest Liver Physiol 2002 : TGF-beta1 or addition of H ( 2 ) O ( 2 ) to HSCs activated p38 MAPK with a rise in procollagen mRNA level ; these changes were blocked by catalase and SB-203580 and likewise by DLPC
Cao et al., Blood 2003 : TGF-beta1 and ATRA activate P42/44 mitogen activated protein ( MAP ) kinase with nearly identical kinetics, ruling out its involvement in these effects on Smad phosphorylation
Frippiat et al., Free Radic Biol Med 2002 : Here we show that sustained p38 ( MAPK ) phosphorylation is responsible for both H2O2 induced overexpression of TGF-beta 1 and subsequent TGF-beta 1-induced appearance of these biomarkers
Fukuda et al., Virology 2002 (Cell Transformation, Neoplastic...) : TGF-beta 1 activated MAPK ( ERK 1/2 ) and p21 in the TGF-beta 1-susceptible cell line HSC-39 but not in GT38 cells
Selvamurugan et al., FEBS Lett 2002 (Breast Neoplasms...) : These data indicate that TGF-beta1 induced MAPK and Smad pathways are involved in TGF-beta1 stimulated collagenase-3 expression in MDA-MB231 cells
Zhou et al., Zhonghua Yi Xue Za Zhi 2002 : Furthermore, the functional and structural results showed that Ox-LDL regulates rat TGF-beta(1) gene expression through AP-1 binding site and c-Jun/AP-1 complex, it gives rise to the involvement of protein kinase C, but not p38MAPK , in Ox-LDL induced TGF-beta(1) gene expression
Burt et al., Diabetologia 2003 : Glucose induced TGFbeta1 expression is mediated by p38 mitogen-activated-protein-kinase ( p38-MAPK ) and this kinase is activated in the diabetic glomeruli ... P38-MAPK inhibition using SB202190 ( 1 micro mol/l ) reduced hexosamine induced TGFbeta1 expression in normal and high glucose
Mincione et al., Exp Cell Res 2003 : These results were accompanied by TGF-beta 1 inhibition of IGF-I stimulated mitogen activated protein kinase phosphorylation and activation
Hubchak et al., J Am Soc Nephrol 2003 : It also was determined that TGF-beta1 activates ERK mitogen activated protein kinase in mesangial cells to enhance Smad activation and collagen expression
Frank et al., J Biol Chem 2003 : The inhibitory effect of TGF-beta1 on sodium uptake and alphaENaC expression in ATII cells was mediated by activation of the MAPK , ERK1/2
Horowitz et al., J Biol Chem 2004 : Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 MAPK dependent induction of an autocrine growth factor
Kim et al., J Biol Chem 2004 (Carcinoma, Hepatocellular...) : Although transforming growth factor beta1 ( TGF-beta1 ) acts via the Smad signaling pathway to initiate de novo gene transcription, the TGF-beta1 induced MAPK kinase activation that is involved in the regulation of apoptosis is less well understood
Falanga et al., Wound Repair Regen 2004 : By Western blot analysis, Smad3 null mice fibroblasts showed a compensatory increase in mitogen activated protein kinase phosphorylation in response to transforming growth factor-beta1 , suggesting that mitogen activated protein kinase overcompensation together with loss of Smad3 may be involved in the modulation of faster healing
Lechuga et al., Am J Physiol Gastrointest Liver Physiol 2004 : Our results also show that this TGF-beta1 mediated effect is de novo protein synthesis dependent and requires the activity of p38MAPK , phosphatidylinositol 3-kinase, AKT, and p70 ( S6k )
Munshi et al., J Biol Chem 2004 (Carcinoma, Squamous Cell...) : TGF-beta1 induced concomitant activation of ERK1/2 and p38 MAPK , and kinase inhibition studies revealed a negative regulatory role for ERK1/2 in modulating acquisition of MMP-2 activity
Suzuki et al., Clin Exp Nephrol 2004 : Role of mitogen activated protein kinase in the regulation of transforming growth factor-beta induced fibronectin accumulation in cultured renal interstitial fibroblasts
Rhyu et al., J Am Soc Nephrol 2005 (Fibrosis...) : Role of reactive oxygen species in TGF-beta1 induced mitogen activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells ... Antioxidants effectively inhibited TGF-beta1 induced cellular ROS, phosphorylation of Smad 2, p38 MAPK , and ERK, and EMT ... Because reactive oxygen species ( ROS ) are involved in TGF-beta1 signaling and are upstream signaling molecules to MAPK, this study examined the role of ROS in TGF-beta1 induced MAPK activation and EMT in rat proximal tubular epithelial cells
Nakagawa et al., J Am Soc Nephrol 2005 : In conclusion, TSP-1 expression is regulated by both ERK1/2 and p38 MAPK in rat proximal tubular cells and mouse fibroblasts in response to TGF-beta1
Roux et al., J Biol Chem 2005 (Edema) : The inhibitory effect of IL-1beta on alpha ENaC expression was mediated by the activation of p38 MAPK in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta
Leung et al., Nephrol Dial Transplant 2005 : The GDP induced VEGF and transforming growth factor ( TGF ) -beta synthesis in HPMC was partially reduced by either the p42/p44 MAPK inhibitor ( PD98059 ) or the PKC inhibitor ( staurosporine )
Han et al., J Clin Invest 2005 (Carcinoma in Situ...) : However, Delta ( beta ) RII did not alter TGF-beta1 mediated expression of RhoA/Rac and MAPK , which contributed to increased metastasis
Fang et al., J Cell Biochem 2005 : Nicotine treatment down-regulated TGF-beta1 induced p38 MAPK phosphorylation
Deaton et al., J Biol Chem 2005 : Finally, examination of MAPK signaling demonstrated that TGF-beta1 increased the activity of p38 MAPK , which was required for activation of the SMC marker gene promoters
Khalil et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-beta1 induced release of extracellular fibroblast growth factor-2 and phosphorylation of p38 MAPK and JNK
Itagaki et al., Gut 2005 : Oestradiol inhibited ROS generation and antioxidant enzyme loss via the suppression of NADH/NADPH oxidase activity, and attenuated hydrogen peroxide induced transforming growth factor-beta1 ( TGF-beta1 ) expression, HSC proliferation and transformation, and the activation of mitogen activated protein kinase ( MAPK ) pathways and transcription factors
McGillicuddy et al., Vascul Pharmacol 2006 (Coronary Restenosis...) : Fluvastatin abolished TGF-beta1 induced phosphorylation of p38 MAPK and TGF-beta1 induced TSP-1 expression
Pelaia et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : Within such a context, the aim of our study was to investigate, in primary cultures of normal and fibrotic human lung fibroblasts ( HLFs ), the effects of TGF-beta1 on mitogen activated protein kinase ( MAPK ) phosphorylation, cell proliferation, and production of interleukins 6 (IL-6) and 11 ( IL-11 ), in the presence or absence of a pretreatment with budesonide ( BUD ) ... TGF-beta1 ( 10 ng/ml ) significantly stimulated MAPK phosphorylation ( P < 0.01 ), and also enhanced cell proliferation as well as the secretion of both IL-6 and IL-11, which reached the highest increases at the 72nd h of cell exposure to this growth factor
Ferrari et al., Proc Natl Acad Sci U S A 2006 : Inhibition of VEGF signaling through VEGF receptor 2 ( flk-1 ) abrogates TGF-beta1 induced apoptosis and p38 ( MAPK ) activation ... Inhibition of p38 ( MAPK ) blocks TGF-beta1 induced apoptosis, showing that VEGF/flk-1 mediated activation of p38 ( MAPK ) is required for TGF-beta1 induction of apoptosis
Gui et al., Dig Dis Sci 2007 : Furthermore, emodin markedly inhibited TGFbeta1 induced p42/p44 mitogen activated protein kinase phosphorylation but did not alter PMA induction
Kim et al., American journal of physiology. Renal physiology 2007 : TGF-beta activated kinase 1 and TAK1 binding protein 1 cooperate to mediate TGF-beta1 induced MKK3-p38 MAPK activation and stimulation of type I collagen ... Transient overexpression of TAK1 with TAB1 enhanced the activation of MKK3 and p38 MAPK with or without TGF-beta(1) stimulation, whereas a dominant negative mutant of TAK1 ( TAK1DN ) suppressed TGF-beta(1) induced activation of MKK3 and p38 MAPK
Luo et al., Zhonghua Yi Xue Za Zhi 2006 : The present study was designed to evaluate the role of MAPK/ERK1/2 phosphorylation in mediating the synthesis of TGF-beta1 in renal tubular epithelial cells that was activated by aldosterone
Huang et al., Kidney Int 2007 : Renin stimulated TGF-beta1 expression is regulated by a mitogen activated protein kinase in mesangial cells
Hu et al., Am J Physiol Heart Circ Physiol 2007 (Anoxia...) : TGF-beta(1) overexpression also blocked H-R mediated p38 and p44/42 MAPK activation
Cailotto et al., Arthritis Res Ther 2007 (Chondrocalcinosis...) : Induction of Ank by TGF-beta1 required activation of the extracellular signal regulated kinase ( ERK ) pathway but not of p38-mitogen activated protein kinase or of protein kinase A
Akel et al., Platelets 2007 (Leukemia, Erythroblastic, Acute...) : Stable over-expression of Smad7 in K562 cells ( K562/7 ) prevented activation of Smad2/3 and MAPK ( ERK1/2, p38 and JNK1/2 ) proteins by activin-A/TGF-beta1 and subsequent induction of erythroid differentiation
Pechkovsky et al., J Biol Chem 2008 (MAP Kinase Signaling System) : In addition, echistatin inhibited TGFbeta1 induced p38 MAPK but not Smad3 activation ... Furthermore, inhibition of the Src family kinases, but not focal adhesion kinase, completely abrogated TGFbeta1 induced expression of alphavbeta3 and p38 MAPK phosphorylation but not beta5 integrin expression and Smad3 activation
Ding et al., J Biol Chem 2008 (Disease Models, Animal...) : FRNK overexpression blocks TGF-beta1 induced ERK or p38 MAPK activation in the presence, and surprisingly, in the absence of FAK
Zimpelmann et al., American journal of physiology. Renal physiology 2009 (MAP Kinase Signaling System) : Stimulation of p38 MAPK phosphorylation by Ang- ( 1-7 ) leads to release of arachidonic acid and production of TGF-beta1 and extracellular matrix proteins
Krug et al., Hypertension 2010 : MR blockade and extracellular signal regulated kinase 1/2 mitogen activated protein kinase inhibition prevent age associated increases of transforming growth factor-beta , intercellular adhesion molecule 1, and procollagen 1
Leenders et al., J Biol Chem 2010 (Hypertrophy, Left Ventricular) : We show that transforming growth factor-beta mediated activation of p38 MAPK is necessary and sufficient to decrease KLF15 expression
Kwon et al., J Endod 2010 : TGFbeta1 induced cell migration and increased the phosphorylation of Hsp27 and p38 MAPK in MDPC-23 cells
Wei et al., Cell Biol Int 2013 : Our present study is to explore the role of AEG-1 in TGF-beta1 induced p38 MAPK activation and EMT process in human renal tubular epithelial ( HK-2 ) cells
Berrou et al., Biochem J 1996 : Transforming growth factor beta 1 inhibits mitogen activated protein kinase induced by basic fibroblast growth factor in smooth muscle cells
Reimann et al., FEBS Lett 1997 : Transforming growth factor-beta1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells
Axmann et al., Biochem Biophys Res Commun 1998 : Inhibition of the binding of growth factors to their tyrosine kinase receptors did not affect MAPK activation by TGF-beta1 ... It is shown that calcium dependent isoforms of PKC are required for MAPK activation by TGF-beta1