Gene interactions and pathways from curated databases and text-mining

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IGF2 — TGFB1

Text-mined interactions from Literome

Edmondson et al., J Cell Physiol 1999 : Expression of insulin-like growth factor binding protein-3 ( IGFBP-3 ) in human keratinocytes is regulated by EGF and TGFbeta1
Wolf et al., Neuroscience 1999 : In the presence of fibroblast growth factor-2 and insulin-like growth factor-II , transforming growth factor-beta1 ( 0.08 nM ) reduced 5-bromo-2'-deoxyuridine labeling by about 50 %, without interfering with chromaffin cell survival or death
Dahiya et al., Int J Impot Res 1999 (Erectile Dysfunction) : The results of these experiments suggest that : ( 1 ) young and old rat penile tissues expressed mRNA transcripts for TGF alpha, TGF beta 1, TGF beta 2, TGF beta 3, IGF and NGF ; ( 2 ) TGF beta 1 gene expression was significantly increased in old rat penile tissues as compared to young ; ( 3 ) mRNA transcripts for NGF and TGF beta 3 were significantly lower in old rat penile tissues as compared to young ; and ( 4 ) TGF alpha, TGF beta 2 and IGF mRNA expression did not change in young and old rat penile tissues
Gray et al., Exp Cell Res 1999 (Carcinoma, Hepatocellular...) : IGF-II enhances trichostatin A-induced TGFbeta1 and p21 ( Waf1,Cip1, sdi1 ) expression in Hep3B cells
Ghahary et al., Growth Factors 2000 : Mannose-6-phosphate/IGF-II receptors mediate the effects of IGF-1 induced latent transforming growth factor beta 1 on expression of type I collagen and collagenase in dermal fibroblasts
Dahlfors et al., Endocrinology 2000 : Vascular endothelial growth factor and transforming growth factor-beta1 regulate the expression of insulin-like growth factor binding protein-3, -4, and -5 in large vessel endothelial cells
Villevalois-Cam et al., J Hepatol 2003 : The hepatocyte is a direct target for transforming-growth factor beta activation via the insulin-like growth factor II/mannose 6-phosphate receptor
Scharf et al., Horm Metab Res 2003 (Carcinoma, Hepatocellular...) : Finally, defective functions of the IGF-II/mannose 6-phosphate receptor involved in degradation of IGF II , the activation of the growth inhibitor TGF-beta1 , and the lysosomal targeting of cathepsin proteases capable to degrade extracellular matrix proteins may contribute to the development of HCC
Zarzyńska et al., J Dairy Res 2005 : Exogenous TGF-beta1, IGF-I , EGF and GH inhibited FBS-deficiency stimulated TGF-beta1 expression
Ilvesmäki et al., J Endocrinol 1993 : Transforming growth factor-beta 1 inhibited IGF-II mRNA accumulation to the same extent as TPA
Lahm et al., Biochem Biophys Res Commun 1996 (Colorectal Neoplasms) : Differential effect of interleukin-4 and transforming growth factor beta 1 on expression of proto-oncogenes and autocrine insulin-like growth factor II in colorectal carcinoma cells
Hembree et al., J Anim Sci 1996 : Cultured porcine myogenic cells produce insulin-like growth factor binding protein-3 ( IGFBP-3 ) and transforming growth factor beta-1 stimulates IGFBP-3 production
Rydziel et al., Endocrinology 1996 : In conclusion, normal Ob cells express the PDGF-B gene, and TGF beta 1 induces its transcription, whereas bFGF, IGF-I , and PDGF-BB do not enhance the levels of PDGF-B mRNA
Gangji et al., Endocrinology 1998 : We also determined mechanisms involved in the regulation of IGF-II by platelet derived growth factor (PDGF) BB, fibroblast growth factor-2 (FGF-2), and transforming growth factor (TGF) beta1
Lacroix et al., Cancer Lett 1998 (Breast Neoplasms) : The production of Il-11 was increased by transforming growth factor-beta1 in a dose dependent manner with a rapid ( 2 h ) and transient ( 24 h ) mRNA induction, but not by epidermal growth factor, insulin-like growth factor-I and -II , basic fibroblast growth factor, platelet derived growth factor or parathyroid hormone