Marciniak et al., Mol Cancer Ther 2004
(Prostatic Neoplasms) :
These changes were accompanied by a concomitant attenuation of activation of Akt and mitogen activated protein kinases as well as basal and transforming growth factor-alpha induced activation of nuclear factor-kappaB
Cao et al., Science signaling 2009
:
Loss of Galpha ( i1 ) and Galpha ( i3 ) severely impaired the activation of Akt and of p70 S6 kinase and 4E-BP1, downstream targets of mTORC1, in response to EGF, heparin binding EGF-like growth factor, and transforming growth factor alpha , but not insulin, insulin-like growth factor, or platelet derived growth factor