◀ Back to AKT1
AKT1 — TCL1A
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
AKT1
→
TCL1A
(increases, TCL1A Activity)
Laine et al., J Biol Chem 2002*
Evidence: The members of the TCL1 proto-oncogene family (TCL1, MTCP1, and TCL1b) bind to Akt1, increasing its phosphorylation status and kinase activity in contrast to Akt1 and Akt2, which bind to all members of the TCL1 family,
-
OpenBEL Selventa BEL large corpus:
AKT1
→
Complex of AKT1-TCL1A
(directlyIncreases, AKT1/TCL1A Activity)
Laine et al., J Biol Chem 2002*
Evidence: The members of the TCL1 proto-oncogene family (TCL1, MTCP1, and TCL1b) bind to Akt1, increasing its phosphorylation status and kinase activity in contrast to Akt1 and Akt2, which bind to all members of the TCL1 family,
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WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
TCL1A/TCL1B/TCL1B
→
AKT1/AKT3/AKT2
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Bind_translation Interaction:
AKT1
—
TCL1A
(coimmunoprecipitation)
Laine et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
AKT1
—
TCL1A
(physical association, affinity chromatography technology)
Laine et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
AKT1
—
TCL1A
(direct interaction, pull down)
French et al., Biochemistry 2002*
-
IRef Biogrid Interaction:
AKT1
—
TCL1A
(physical association, affinity chromatography technology)
French et al., Biochemistry 2002*
-
IRef Biogrid Interaction:
AKT1
—
TCL1A
(physical association, affinity chromatography technology)
Laine et al., Mol Cell 2000*
-
MIPS CORUM TCL1(trimer)-AKT1 complex:
TCL1(trimer)-AKT1 complex complex (AKT1-TCL1A)
Laine et al., Mol Cell 2000*
-
IRef Corum Interaction:
AKT1
—
TCL1A
(association, two hybrid)
Laine et al., Mol Cell 2000*
-
IRef Corum Interaction:
AKT1
—
TCL1A
(association, coimmunoprecipitation)
Laine et al., Mol Cell 2000*
-
IRef Hprd Interaction:
AKT1
—
TCL1A
(two hybrid)
Laine et al., Mol Cell 2000*, French et al., Biochemistry 2002*
-
IRef Hprd Interaction:
AKT1
—
TCL1A
(in vitro)
Laine et al., Mol Cell 2000*, French et al., Biochemistry 2002*
-
IRef Hprd Interaction:
AKT1
—
TCL1A
(in vivo)
Laine et al., Mol Cell 2000*, French et al., Biochemistry 2002*
-
IRef Ophid Interaction:
AKT1
—
TCL1A
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Pekarsky et al., Proc Natl Acad Sci U S A 2000
:
Tcl1 enhances
Akt kinase activity and mediates its nuclear translocation
Künstle et al., Mol Cell Biol 2002
:
In vitro kinase assays and overexpression experiments in mammalian cells demonstrated that both TCL1-Akt interaction and oligomerization of TCL1 were required for
TCL1 induced
Akt activation and substrate phosphorylation ... The results demonstrate the structural basis of
TCL1 induced activation of
Akt , which causes human T-PLL
Feng et al., Am J Physiol Gastrointest Liver Physiol 2010
(Atrophy) :
We used a novel
Akt activating peptide,
TCL1 ( a head-to-tail dimer of the Akt binding domain of T-cell lymphoma-1 ), or an inactive mutant sequence TCL1G conjugated to a transactivator of transcription peptide sequence to promote intracellular uptake
Popal et al., Leukemia & lymphoma 2010
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
We discuss inhibitory strategies that are based on
TCL1A 's
activation of the growth modulating kinase
AKT and on influences that regulate TCL1A expression
Miyazaki et al., PloS one 2013
:
We found that
Tcl1 expression levels correlated positively with the proliferation rate and negatively with the apoptosis of ES cells, but did not
affect Akt phosphorylation