Gene interactions and pathways from curated databases and text-mining

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NOTCH4 — TCF23

Text-mined interactions from Literome

Das et al., J Biol Chem 2004 : We demonstrate that Notch4/int-3 induced activation of the downstream transcription factor , CSL, is abrogated in cells deficient in presenilins or treated with a pharmacological inhibitor of gamma-secretase/presenilins
Robert-Moreno et al., Development 2005 : Since Notch requires binding to RBPjkappa transcription factor to activate transcription, we analyzed the aorta of the para-aortic splanchnopleura/AGM in RBPjkappa mutant embryos
Kinameri et al., PloS one 2008 : An evolutionary conserved program consisting of Notch signalling mediated by basic Helix-Loop-Helix ( bHLH ) transcription factor activity is necessary for both the maintenance of neural progenitor cell character and the progression of neurogenesis ; however, additional players in mammalian CNS neural specification remain largely unknown
Lee et al., Mol Cancer Res 2009 : Activation of SRC/STAT3 pathway by Notch signaling was dependent on the expression of Notch effector HES1 transcription factor
Brimer et al., Oncogene 2012 : BPV-1 induced papillomas show characteristics of repressed NOTCH signal transduction, including suprabasal expression of integrins, talin and basal type keratins, and delayed expression of the NOTCH dependent HES1 transcription factor
Matsuda et al., J Neurosci 2012 : The High Mobility Group ( HMG ) -box transcription factor , Sox2, and the cell surface activated transcriptional regulator, Notch , play important roles in CNS stem cells
Chen et al., PloS one 2012 : We further showed that, by using a conditional knockout model of RBP-J ( the critical transcription factor mediating Notch signaling ), Notch signaling differentially regulates EEPCs and EOCs