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AKT1 — TBL1XR1
Text-mined interactions from Literome
Lefebvre et al., Mol Endocrinol 2006
:
Through direct phosphorylation of the corepressor silencing mediator for retinoic and thyroid hormone receptors ( SMRT ),
Akt stabilized
RAR/SMRT interaction, leading to an increased tethering of SMRT to the RARbeta2 promoter, decreased histone acetylation, down-regulation of the RARbeta2 expression, and impaired cellular differentiation in response to retinoid
Furuya et al., Mol Cell Biol 2007
(Thyroid Neoplasms) :
Conversely, lowering cellular
NCoR by siRNA knockdown in tumor cells
led to overactivated
p-AKT and increased cell proliferation and motility
Furuya et al., Steroids 2009
(Thyroid Neoplasms) :
Over-expression of
NCoR in thyroid tumor cells of TRbeta ( PV/PV ) mice
reduces AKT-mTOR-p70 ( S6K ) signaling ... Conversely, lowering cellular
NCoR by siRNA knockdown in tumor cells
leads to over activated
PI3K-AKT signaling to increase cell proliferation and motility