Vitagliano et al., Cancer Res 2004
(MAP Kinase Signaling System...) :
Therefore, in thyroid cancer, RET/PTC mediated MAPK activation contributes to p27Kip1 deregulation
Mitsutake et al., Endocrinology 2006
(Carcinoma, Papillary...) :
BRAF mediates RET/PTC induced mitogen activated protein kinase activation in thyroid cells : functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis ... The requirement for BRAF in RET/PTC mediated MAPK activation and gene expression has not been tested functionally ... These data indicate that BRAF is required for RET/PTC induced MAPK activation in thyroid cells and support the notion that BRAF inactivation may be an attractive target for PTCs
Iavarone et al., J Biol Chem 2006
(MAP Kinase Signaling System...) :
Activation of the Erk8 mitogen activated protein ( MAP ) kinase by RET/PTC3 , a constitutively active form of the RET proto-oncogene