Gene interactions and pathways from curated databases and text-mining

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CASP7 — TARDBP

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zhang et al., J Neurosci 2007 (Alzheimer Disease...) : Progranulin mediates caspase dependent cleavage of TAR DNA binding protein-43
Suzuki et al., J Biol Chem 2011 (Amyotrophic Lateral Sclerosis...) : Accumulated evidence indicates that caspases are activated in neurons of ALS and FTLD-U patients, and activated caspase mediated cleavage of TDP-43 generates CTFs of TDP-43
Cassel et al., Biochimie 2012 : Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function ... Here we examine the effects of a series of 4-aminoquinolines with affinity for TDP-43 upon caspase-7 induced cleavage of TDP-43 and TDP-43 cellular function ... Incubation of TDP-43 and caspase-7 in the presence of these compounds stimulated caspase-7 mediated cleavage of TDP-43