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CASP7 — TARDBP
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhang et al., J Neurosci 2007
(Alzheimer Disease...) :
Progranulin mediates
caspase dependent cleavage of
TAR DNA binding protein-43
Suzuki et al., J Biol Chem 2011
(Amyotrophic Lateral Sclerosis...) :
Accumulated evidence indicates that caspases are activated in neurons of ALS and FTLD-U patients, and activated
caspase mediated cleavage of
TDP-43 generates CTFs of TDP-43
Cassel et al., Biochimie 2012
:
Characterization of a series of 4-aminoquinolines that stimulate
caspase-7 mediated cleavage of
TDP-43 and inhibit its function ... Here we examine the effects of a series of 4-aminoquinolines with affinity for TDP-43 upon
caspase-7 induced cleavage of TDP-43 and
TDP-43 cellular function ... Incubation of TDP-43 and caspase-7 in the presence of these compounds stimulated
caspase-7 mediated cleavage of
TDP-43