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AKT1 — TACR1

Text-mined interactions from Literome

Sun et al., FASEB J 2009 (Inflammation) : Additionally, phosphoinositide 3-kinase (PI3K)-Akt was also activated by SP/NK-1R in macrophages
Akazawa et al., J Neurochem 2009 (Brain Neoplasms...) : In the present study we show that stimulation of NK1R in human U373 glioblastoma cells by substance P increases Akt phosphorylation by 2.5-fold, with an EC ( 50 ) of 57 nM ... Experiments designed to elucidate the mechanism of NK1R mediated Akt phosphorylation revealed total involvement of non-receptor tyrosine kinase Src and phosphatidyl-3-kinase, a partial involvement of epidermal growth factor receptor, and no involvement of mitogen activated protein/extracellular signal related kinase
Choi et al., Molecular pain 2012 : We infer from these data that 1 ) phosphorylation of Akt in the deep dorsal horn is dependent on prior activation of NK1 receptor bearing cells in superficial dorsal horn, and 2 ) there are parallel spinal intracellular cascades initiated by the carrageenan injection downstream of PI-3K activation, including one containing Akt and another involving GluA1 trafficking into neuronal plasma membranes that separately lead to enhanced pain behavior