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SYT1 — TLR4

Text-mined interactions from Literome

Lee et al., J Biol Chem 2003 : LY294002, dominant negative ( DN ) phosphatidylinositol 3-kinase (PI3K), or AKT ( DN ) inhibited NFkappaB activation, p65 transactivation, and cyclooxygenase-2 (COX-2) expression induced by lauric acid or constitutively active ( CA ) TLR4
Henning et al., J Immunol 2008 : SP-A decreases the phosphorylation of IkappaBalpha, a key regulator of NF-kappaB activity, and nuclear translocation of p65 which result in diminished TNF-alpha secretion in response to TLR ligands
Yoza et al., Cytokine 2011 (Sepsis) : We further show TLR dependent NF?B p65 and histone H3 serine 10 phosphorylation binding at the promoter
Wu et al., Cell Physiol Biochem 2012 : Ketamine ( 100 and 1000 µM ) reduced the expression of GFAP and the production of these proinflammatory cytokines, inhibited the expression of TLR4 and attenuated the phosphorylation of NF-?B p65 in astrocytes challenged by LPS