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EPO — SYP

Text-mined interactions from Literome

Tauchi et al., Blood 1996 : We found that : ( 1 ) all Epo stimulated mutant EpoRs, except for the Y425F EpoR, coimmunoprecipitated with Syp ; ( 2 ) all Epo stimulated mutant EpoRs, except for the Y425F EpoR, bound to a GST-fusion protein containing both SH2 domains of Syp ; ( 3 ) Jak2 could phosphorylate GST-Syp in vitro after Epo stimulation of wild-type ( wt ) EpoR expressing DA-3 cells ; ( 4 ) Epo stimulated tyrosine phosphorylation of Syp in vivo was markedly reduced in Y425F EpoR expressing DA-3 calls ; and ( 5 ) DA-3 cells expressing the Y425F EpoR grow less well in response to Epo than wt EpoR expressing cells
Sharlow et al., Blood 1997 (Leukemia, Erythroblastic, Acute) : No effects of EPO on levels of HCP, Syp , Stat5, the EPO receptor, or GATA-1 expression were observed during induced differentiation