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SYK — TLR4

Pathways - manually collected, often from reviews:

• WikiPathways Regulation of toll-like receptor signaling pathway: SYK → TLR4 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TLR4 — SYK (physical association, affinity chromatography technology) Lin et al., Science signaling 2013*
• IRef Hprd Interaction: SYK — TLR4 (in vivo) Arndt et al., J Biol Chem 2004*

Text-mined interactions from Literome

Bae et al., Circ Res 2009 (Atherosclerosis) : Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein : toll-like receptor 4- and spleen tyrosine kinase dependent activation of NADPH oxidase 2
Lin et al., Mol Immunol 2010 : Accordingly we found the abilities of TLR3, TLR4 and TLR9 ligands to induce Syk and JNK activation, as evidenced by increased Syk autophosphorylation on Y519/Y520, JNK phosphorylation and both kinase activities
Zhu et al., Int Immunopharmacol 2013 (Disease Models, Animal...) : These findings demonstrated that ß-glucan activation of Dectin1/Syk attenuated LPS induction of TLR4/MyD88/NF-?B and inhibited the LPS induced inflammation factors in mammary epithelial cells, thereby providing a possibly protective effect of ß-glucan in the prevention of LPS induced dysfunction in mammary epithelial cells