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CASP5 — SYK

Text-mined interactions from Literome

Tohyama et al., Curr Pharm Des 2004 (Fanconi Anemia...) : Syk might inhibit the activation of caspase-9 through Akt thereby protecting cells from oxidative stress induced apoptosis
Saïd-Sadier et al., PloS one 2010 : Thus, our data demonstrate that the innate immune response against A. fumigatus infection involves a two step activation process, with a first signal promoting expression and synthesis of pro-IL-1beta ; and a second signal, involving Syk induced activation of the NLRP3 inflammasome and caspase-1 , allowing processing and secretion of the mature cytokine
Abdul-Sater et al., Microbes Infect 2010 : Atypically for a bacterial infection, caspase-1 activation during chlamydial infection also involves partially the spleen tyrosine kinase (Syk) , which is usually associated with a pathogen recognition receptor for fungal pathogens
Lee et al., Immunol Cell Biol 2012 (Mycobacterium Infections, Nontuberculous) : Dectin-1 dependent Syk signaling, but not that of MyD88, led to the activation of caspase-1 and secretion of IL-1ß through the activation of an NLRP3/apoptosis associated speck-like protein containing a caspase recruitment domain (ASC) inflammasome
Lu et al., PLoS Pathog 2012 (Inflammation...) : Blocking Syk activation by kinase inhibitors or RNAi reduced Syk phosphorylation, lysosomal destabilization, ROS production, and caspase-1 activation in Ceacam1?/? neutrophils