Gene interactions and pathways from curated databases and text-mining

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AKT1 — SYK

Text-mined interactions from Literome

Li et al., Proc Natl Acad Sci U S A 1999 : BCR induced activation of Akt/PKB required the tyrosine kinase Syk , which was not previously known to regulate Akt/PKB ... Our results show that Lyn provides a mechanism for negative regulation and opposes the effect of Syk on BCR mediated activation of Akt/PKB ... Our results show that Lyn provides a mechanism for negative regulation and opposes the effect of Syk on BCR mediated activation of Akt/PKB
Gold et al., J Immunol 1999 : Complementary experiments in BCR expressing AtT20 endocrine cells confirmed that Src kinases are sufficient for BCR induced Akt phosphorylation, but that Syk is required for sustained phosphorylation of Akt on both serine 473 and threonine 308
Craxton et al., J Biol Chem 1999 : BCR mediated Akt activation required Syk and was partially dependent upon Btk
Pogue et al., J Immunol 2000 : Using various DT40 knockout cell lines, we further demonstrate that the tyrosine kinase Syk is required for Akt activation and that Lyn tyrosine kinase inhibits Akt activation
Ding et al., J Biol Chem 2000 : Pretreatment with wortmannin, a PI 3-kinase-specific inhibitor, completely blocked the Syk dependent Akt activation
Kitaura et al., J Exp Med 2000 : Phosphorylation of Akt is regulated positively by Btk and Syk and negatively by Lyn
Qin et al., Biochemistry 2003 : Under our conditions, hydrogen peroxide induced PI3K and Akt activation was independent of Lyn, Syk , Cbl, BCAP, or Ras when each was eliminated individually either by mutation or by a specific inhibitor
Andreae et al., Blood 2003 : Engagement of class II molecules by both its natural ligand LAG-3 and class II mAb induces rapid protein phosphorylation of phospholipase Cgamma2 ( PLCgamma2 ) and p72syk as well as activation of phosphatidyl inositol 3-kinase/Akt , p42/44 extracellular signal regulated protein kinase, and p38 mitogen activated protein kinase pathways
Mikhalap et al., Blood 2004 (MAP Kinase Signaling System) : CD150 mediated Akt phosphorylation required Syk and SH2D1A, was negatively regulated by Lyn and Btk, but was SHIP independent
Buchner et al., Blood 2010 (Leukemia, Lymphocytic, Chronic, B-Cell) : Chemokine and integrin stimulation induced SYK phosphorylation, SYK dependent Akt phosphorylation, and F-actin formation in primary CLL cells
Hatton et al., J Biol Chem 2011 (Epstein-Barr Virus Infections...) : Syk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2 dependent loss of X-linked inhibitor of apoptosis protein ( XIAP ) to promote survival of Epstein-Barr virus+ ( EBV+ ) B cell lymphomas
Hatton et al., PloS one 2012 (Lymphoma, B-Cell) : Using small molecule inhibition and siRNA strategies in human B cell lines expressing a chimeric, signaling-inducible LMP1 protein, nerve growth factor receptor (NGFR)-LMP1, we show that NGFR-LMP1 utilizes Syk to activate PI3K/Akt signaling and induce IL-10 production
Hatton et al., Am J Transplant 2013 (Epstein-Barr Virus Infections...) : Taken together, our data indicate that Syk activates PI3K/Akt signaling which is required for survival of EBV+ B cell lymphomas
Xia et al., Int Immunopharmacol 2013 : Furthermore, we found that MED suppressed antigen induced activation of Syk , and subsequently inhibited the phosphorylation of PLC?1, Akt , and MAPKs such as extracellular signal regulated kinase ( ERK ), c-jun N-terminal kinase ( JNK ), and p38 in mast cells
Miranti et al., Curr Biol 1998 : Additionally, Syk and Vav1 cooperatively induced activation of Jun N-terminal kinase (JNK), extracellular-signal regulated kinase 2 ( ERK2 ) and the kinase Akt , and phosphorylation of the oncoprotein Cbl in fibrinogen-adherent cells