Peng et al., J Gastrointest Surg 2010
(Disease Models, Animal...) :
LKB1 phosphorylates AMPK and may activate SIRT1 Morales-Alamo et al., J Appl Physiol 2012
(Acute Disease...) :
This could have led to lower liver kinase B1 (LKB1) activation by SIRT1 and, hence, blunted Thr ( 172 ) -AMPKa phosphorylation ... Collectively, our results indicate that the signaling response to sprint exercise in human skeletal muscle is altered in severe acute hypoxia, which abrogated Thr ( 172 ) -AMPKa phosphorylation, likely due to lower LKB1 activation by SIRT1