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IL12A — STAT6
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Levings et al., J Immunol 1999
:
These data show that
STAT6 is
required for the IL-4 mediated inhibition of the production of TNF-alpha and
IL-12 stimulated by LPS alone, but that IL-4 also activates distinct, STAT6 independent mechanism(s) that inhibit the IFN-gamma mediated enhancement of IL-12 and TNF-alpha production
Fujimoto et al., Int Immunol 2002
:
Since
IL-12 induced STAT4 and IL-4 induced
STAT6 activation is sustained in SOCS-1 ( -/- ) T cells, the enhanced T ( h ) functions in SOCS-1 ( -/- ) and SOCS-1 ( +/- ) mice appear to be due to the enhanced effects of these cytokines
Filén et al., Mol Cell Proteomics 2009
:
Besides T cell receptor signaling,
IL-12 induced STAT4 and T-bet- and IL-4 induced
STAT6 and GATA3 signaling pathways are the major players regulating the Th1 and Th2 differentiation process, respectively
Aerts et al., Clin Exp Rheumatol 2010
(Arthritis, Rheumatoid) :
Peripheral blood mononuclear cells ( PBMC ) were analysed flow cytometrically either directly after isolation or after 24 hours of anti-CD3/anti-CD28 stimulation, to determine spontaneous and
IL-4/IL-12 induced STAT4 and
STAT6 phosphorylation in CD4+ T cells
Huang et al., Mol Biol Rep 2012
:
STAT4 and
STAT6 were
activated by
interleukin (IL)-12 and IL-4 stimulation, which were important for the generation of Th1 and Th2 cells
Yin et al., Cancer Lett 2012
(Colonic Neoplasms...) :
Mechanistic studies revealed that over-expression of
IL-12 reduced the expression of IL-4 and
STAT6 in CSCs
Moriggl et al., J Immunol 1998
:
In Th1 cells,
IL-12 activated both STAT6 and STAT4, and IL-4
activated STAT6 , but in both cases the Th1 phenotype remained