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IL22 — STAT5A
Pathways - manually collected, often from reviews:
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BioCarta il22 soluble receptor signaling pathway:
STATs (STAT3/STAT5A/STAT1/STAT5A/STAT5B/STAT5B)
→
IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1)
(modification, collaborate)
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BioCarta il22 soluble receptor signaling pathway:
IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1)
→
STATS/STATS complex (STAT3_STAT5A_STAT1_STAT5A_STAT5B_STAT5B)
(modification, activates)
Text-mined interactions from Literome
Binder et al., Assay Drug Dev Technol 2008
(Leukemia, Erythroblastic, Acute) :
STAT5 is phosphorylated by several JAKs, including Jak3, Jak2, and Tyk2, in
response to interleukin-2, erythropoietin (EPO), and
interleukin-22 , respectively
Hoefsloot et al., Blood 1997
(Myelodysplastic Syndromes) :
In contrast,
interleukin-3 induced a normal
STAT5 response in MDS cells
Ozaki et al., Blood 1998
:
Furthermore,
interleukin-3 (IL-3), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and erythropoietin also
induce Crkl-STAT5 complex formation in responding cells in a stimulation dependent manner