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IL12A — STAT5A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Matikainen et al., Blood 1999
:
IL-12 induced STAT4 and IL-2 and IL-15 induced
STAT5 binding to the GAS elements
Quelle et al., Mol Cell Biol 1995
:
In contrast, IL-2, IL-3, and erythropoietin
induce the tyrosine phosphorylation of
Stat5 while
IL-12 uniquely induces the tyrosine phosphorylation of Stat4
Gollob et al., Blood 1998
:
To understand how the activation of these STATs contributes to T-cell IL-12 responsiveness, we analyzed the
IL-12 induced
activation of
STAT5 and STAT1 in T cells stimulated to undergo Th1 or Th2 differentiation ... The
IL-12 induced tyrosine phosphorylation of
STAT5 and STAT1, but not STAT4, is augmented in T cells activated into Th1 cells with PHA + interferon-gamma (IFN-gamma) compared with T cells activated with PHA alone ...
STAT5 DNA binding
induced by
IL-12 is also augmented in T cells activated with PHA + IFN-gamma compared with T cells activated with PHA alone, whereas STAT4 DNA binding is not increased
Ahn et al., J Immunol 1998
:
2D6 ( IL-12 ) and 2D6 ( IL-2 ) similarly proliferating in response to
IL-12 induced comparable levels of JAK2 activation and
STAT5 phosphorylation ... JAK2 was associated with STAT5, and
IL-12 induced
STAT5 phosphorylation was elicited in the absence of JAK3 activation