Gene interactions and pathways from curated databases and text-mining

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IL12A — STAT5A

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Matikainen et al., Blood 1999 : IL-12 induced STAT4 and IL-2 and IL-15 induced STAT5 binding to the GAS elements
Quelle et al., Mol Cell Biol 1995 : In contrast, IL-2, IL-3, and erythropoietin induce the tyrosine phosphorylation of Stat5 while IL-12 uniquely induces the tyrosine phosphorylation of Stat4
Gollob et al., Blood 1998 : To understand how the activation of these STATs contributes to T-cell IL-12 responsiveness, we analyzed the IL-12 induced activation of STAT5 and STAT1 in T cells stimulated to undergo Th1 or Th2 differentiation ... The IL-12 induced tyrosine phosphorylation of STAT5 and STAT1, but not STAT4, is augmented in T cells activated into Th1 cells with PHA + interferon-gamma (IFN-gamma) compared with T cells activated with PHA alone ... STAT5 DNA binding induced by IL-12 is also augmented in T cells activated with PHA + IFN-gamma compared with T cells activated with PHA alone, whereas STAT4 DNA binding is not increased
Ahn et al., J Immunol 1998 : 2D6 ( IL-12 ) and 2D6 ( IL-2 ) similarly proliferating in response to IL-12 induced comparable levels of JAK2 activation and STAT5 phosphorylation ... JAK2 was associated with STAT5, and IL-12 induced STAT5 phosphorylation was elicited in the absence of JAK3 activation