Gene interactions and pathways from curated databases and text-mining

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NOTCH4 — STAT3

Text-mined interactions from Literome

Kamakura et al., Nat Cell Biol 2004 : Here we show that STAT3 is activated in the presence of active Notch , as well as the Notch effectors Hes1 and Hes5
Gouti et al., Stem Cells 2008 : This was partially attributed to Hoxb1 dependent activation of the Notch signaling pathway and Notch dependent STAT3 phosphorylation at Ser 727, thus linking Hox gene function with maintenance of active Notch signaling and the JAK/STAT pathway
Lee et al., Mol Cancer Res 2009 : SRC kinase was found to be responsible for the enhanced STAT3 phosphorylation in response to Notch signaling
Bhoopathi et al., Cancer Res 2011 (Brain Neoplasms...) : Taken together, our results suggest that SPARC induces expression of neuronal markers in medulloblastoma cells through its inhibitory effect on IL-6 regulated suppression of Notch pathway mediated STAT3 signaling, thus giving further support to the potential use of SPARC as a therapeutic candidate for medulloblastoma treatment