Gene interactions and pathways from curated databases and text-mining

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IGF2 — STAT3

Text-mined interactions from Literome

Zong et al., J Biol Chem 2000 : Dominant negative JAK1 or JAK2 was able to block the IGF-IR mediated tyrosine phosphorylation of STAT3 in 293T cells
Zhang et al., Mol Cell Biol 2006 : Overexpression or downregulation of RACK1 greatly enhances or decreases, respectively, IR/IGF-1R mediated activation of STAT3 and its target gene expression
Ray et al., Int J Oncol 2007 (Breast Neoplasms...) : MCF-7 cells expressed higher levels of Ob-Rb, Jak2, PI3K, Stat3 and p-Stat3 in a dose dependent manner to 50 ng/ml at 24 h ; and IGF-IRalpha increased at 24 h. Cyclin D1 and Cox-2 levels increased with leptin treatment
Wang et al., J Biol Chem 2008 : Interestingly, the expression of the IGF2 gene and the HGF gene is also regulated by JAK2/STAT2/STAT3 , suggesting that this pathway could also promote differentiation by regulating signaling molecules known to be involved in myogenic differentiation