Gene interactions and pathways from curated databases and text-mining

◀ Back to AKT1

AKT1 — STAT3

Text-mined interactions from Literome

Alonzi et al., Mol Cell Neurosci 2001 : To assess the relative importance of these pathways in promoting the survival of cytokine dependent neurons, we conditionally inactivated STAT3 in mice and inhibited MEK, PI3K, and Akt in cultured neurons using pharmacological reagents and by expressing specific inhibitory proteins
Frost et al., Mol Cancer Ther 2002 : In signaling studies, addition of stem cell factor (SCF) induced phosphorylation of ERK and Akt by WTKit, and ERK, Akt and STAT3 by V560GKit, which were all blocked by Imatinib
Duensing et al., Oncogene 2004 (Gastrointestinal Neoplasms) : Using GIST in vitro models, we showed that activation of MAPK p42/44, AKT , and S6K was KIT dependent , whereas STAT1 and STAT3 phosphorylation was only partially dependent on KIT activation
Xu et al., Oncogene 2005 (Neoplasms) : We further demonstrate that Stat3 regulates expression of Akt , which is required for growth signal induced HIF-1 upregulation
Shair et al., PLoS Pathog 2007 (Cell Transformation, Neoplastic...) : The lymphoma cells have deregulated cell cycle markers, and inhibitors of Akt , NFkappaB, and Stat3 block the enhanced viability of LMP1 transgenic lymphocytes and lymphoma cells in vitro
Lu et al., Cell Physiol Biochem 2008 : Inhibition of AKT activity by a dominant negative AKT construct or by a PI3K inhibitor reduced active NF-kappaB and STAT3 expression without significantly altering the activity of the latter
Fuglesteg et al., Basic Res Cardiol 2008 (Disease Models, Animal...) : Inhibiting STAT3 by AG490, or STAT3 depletion in cardiac myocytes affects activation of Akt , suggesting close interaction between STAT3 and Akt in the cardioprotective signalling pathway activated by insulin treatment at reperfusion
Quaglino et al., BMC cell biology 2009 : In addition, we found that mammary cell stretching triggered involution associated cellular events as Leukemia Inhibitory Factor (LIF) expression induction, STAT3 activation and AKT phosphorylation inhibition
Sakai et al., J Dent Res 2010 : VEGF induced ERK and AKT phosphorylation ( indicative of differentiation ), while inhibiting phosphorylation of STAT3 ( indicative of ` stemness ' )
Wang et al., PloS one 2010 (Reperfusion Injury) : TLR4-deficiency was also associated with decreased phosphorylation of PI-3K and AKT , but increased activation of STAT3
Bito et al., Journal of skin cancer 2011 : These data suggest that Stat3 activation through EGFR and/or PI3K/Akt activation plays a critical role in the proliferation and survival of human cutaneous SCC
Dhingra et al., PloS one 2011 : Akt regulates IL-10 mediated suppression of TNFa induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylation
Gu et al., Molecular cancer 2011 (Carcinoma, Hepatocellular...) : IL-17 induces AKT dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma
Liu et al., Toxicological sciences : an official journal of the Society of Toxicology 2012 : JNK dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure
Tu et al., J Cell Physiol 2013 (Arthritis, Rheumatoid...) : Transfection of dominant negative Akt or application of PI3K inhibitorLY294002 significantly inhibited p-Tyr705-STAT3 , p-Ser727-STAT3, and PLGF expression, indicating that Akt is involved in JAK3/STAT3/PLGF signaling cascade
Bento et al., J Dent Res 2013 (MAP Kinase Signaling System) : Exposure of SHED to EGM2-MV supplemented with VEGF induced potent activation of ERK and Akt signaling, while it inhibited phosphorylation of STAT3
Sims et al., PloS one 2013 : Imatinib reverses doxorubicin resistance by affecting activation of STAT3 dependent NF-?B and HSP27/p38/AKT pathways and by inhibiting ABCB1