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STAT1 — TLR4

Text-mined interactions from Literome

Rhee et al., J Biol Chem 2003 : These studies show that engagement of TLR2 and TLR4 leads to rapid phosphorylation of the transcription factor STAT1 at serine 727 ( Ser-727 STAT1 ) in murine macrophages ... Only TLR4 engagement induced STAT1 phosphorylation at tyrosine 701, although this response was delayed compared with Ser-727 STAT1 phosphorylation ... Inhibition of phosphatidylinositol 3'-kinase using LY294002 blocked TLR4 induced STAT1 tyrosine phosphorylation, but this inhibitor had no effect on STAT1 serine phosphorylation ... TLR induced phosphorylation of Ser-727 STAT1 could be blocked by the selective p38 mitogen activated protein kinase inhibitor SB203580 ... TLR2 induced activation of Ser-727 STAT1 phosphorylation required the adapter protein MyD88, whereas TLR4 induced activation of Ser-727 STAT1 phosphorylation was not solely dependent on MyD88 ... Lastly, TLR4 induced activation of Ser-727 STAT1 phosphorylation could be blocked by rottlerin, a specific inhibitor of protein kinase C-delta
Punturieri et al., J Immunol 2004 : Specific engagement of TLR4 or TLR3 does not lead to IFN-beta mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages
Shoenfelt et al., J Endotoxin Res 2006 : TLR2- and TLR4 dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-delta independent ... Previous studies demonstrated that TLR2 and TLR4 engagement leads to rapid phosphorylation of the transcription factor STAT1 at serine 727 ( Ser-727 STAT1 ) in murine macrophages ... Only TLR4 engagement induced STAT1 phosphorylation at tyrosine 701, although this response was delayed compared with Ser-727 STAT1 phosphorylation ... Unlike other cell types, the p38 mitogen activated protein kinase was necessary, but not sufficient, for TLR induced phosphorylation of Ser-727 STAT1 in macrophages
Rothlin et al., Cell 2007 (Inflammation) : TLR induction of IFNAR-STAT1 signaling upregulates the TAM system, which in turn usurps the IFNAR-STAT1 cassette to induce the cytokine and TLR suppressors SOCS1 and SOCS3
Bhattacharyya et al., Proc Natl Acad Sci U S A 2011 : GC attenuates TLR4 mediated STAT1 activation only through induction of suppressor of cytokine signaling 1 ( SOCS1 ), which increases throughout the 6-h period after treatment
Tel et al., Cancer Immunol Immunother 2012 : Furthermore, oxaliplatin decreased TLR induced STAT1 and STAT3 expression, and NF-?B mediated responses