Gene interactions and pathways from curated databases and text-mining

◀ Back to MAPK14

MAPK14 — STAT1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lin et al., Am J Physiol 1999 : T4-directed STAT1alpha Ser-727 phosphorylation is MAPK mediated and results in potentiated STAT1alpha activation and enhanced IFN-gamma activity
Kovarik et al., Proc Natl Acad Sci U S A 1999 (MAP Kinase Signaling System) : Stress induced phosphorylation of STAT1 at Ser727 requires p38 mitogen activated protein kinase whereas IFN-gamma uses a different signaling pathway ... An essential role for p38 MAPK activity in STAT1 Ser727 phosphorylation was confirmed by using cells expressing an SB203580-resistant p38 MAPK
Takauji et al., J Leukoc Biol 2002 : CpG-DNA induced IFN-alpha production involves p38 MAPK dependent STAT1 phosphorylation in human plasmacytoid dendritic cell precursors ... These results suggest that CpG DNA induces p38 MAPK dependent phosphorylation of STAT1 in a manner independent of IFN-alpha/beta, which may cause ISGF3 formation to increase the transcription of the IRF-7 gene, thereby leading to IFN-alpha production in human PDC
Xu et al., Mol Cell Biol 2003 : Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen activated protein kinase mediated serine 727 phosphorylation of Stat1 and Stat3
Nguyen et al., J Interferon Cytokine Res 2003 : Analyses of mutant I1A cells, which lack the IL-1 receptor associated kinase (IRAK), and of I1A cells reconstituted with deletion mutants of IRAK show that the IL-1 mediated phosphorylation of Stat1 on serine requires the IRAK protein but not its kinase activity and does not involve phosphatidylinositol-3'-kinase (PI3K) or the mitogen activated protein ( MAP ) kinases p38 or ERK
Wang et al., Free Radic Biol Med 2003 : V2O5 suppressed H2O2 for as long as 24 h. Differences in the temporal activation of STAT-1 and p38 MAPK were observed following V2O5 or H2O2 treatment, and STAT-1 activation by V2O5 or H2O2 was attenuated by an inhibitor of the EGF receptor tyrosine kinase ( AG1478 ) or p38 MAPK ( SB203580 ) ... Moreover, p38 MAPK and EGF receptor activation are required for V2O5 induced STAT-1 activation
Choudhury et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Inhibition of MAPK activity blocked IFN-gamma induced serine phosphorylation of STAT1alpha ; but its tyrosine phosphorylation and DNA binding were partially inhibited
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Inhibitors of Janus kinase ( JAK ), p38 MAPK , and MAPK/ERK kinase (MEK) suppressed prolactin- plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and NF-kappaB, STAT1 , and IRF-1 activities
Kanda et al., Eur J Immunol 2007 : Inhibitors of PI3 K, p38 MAPK , and MEK suppressed IL-18 plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and NF-kappaB, STAT1 , and IRF-1 activities
Hu et al., J Invest Dermatol 2008 (Adenocarcinoma...) : Although STAT1 phosphorylation required JNK and p38MAPK activation, only JNK activation was essential for IRF1 promoter activation by Tie2-R849W
Yang et al., Microvasc Res 2009 (AIDS Dementia Complex) : Inhibitors of STAT1, mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120 induced monocyte adhesion and migration across in vitro BBB models
Benco et al., Reproduction 2009 : Overexpression of STAT1 reversed the effect of ghrelin on STAT1, PCNA, PGF, OXT ( from stimulatory to inhibitory ), BCL2, P ( 4 ) ( from inhibitory to stimulatory ), prevented ghrelin effect on caspase-3 and BAX, but did not affect ghrelin 's effect on MAPK/ERK1,2 expression
Bhattacharjee et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Further, we found that Src tyrosine kinase mediated activation of p38 MAPK is required for Stat1 and Stat3 serine 727 phosphorylation in alternatively activated monocytes/macrophages
Blank et al., Exp Cell Res 2013 : We first found that p38 MAPK is involved in serine STAT1 phosphorylation, since a reduction of phophoserine-STAT1 levels was evident after incubating WISH cells with cyclic peptide in the presence of a p38 pharmacological inhibitor or a dominant negative p38 mutant ... In conclusion, we herein demonstrated that STAT1 serine phosphorylation is mediated by the sequential activation of PI3K, PKCd and p38 MAPK
Rajotte et al., Blood 1996 : Finally, expression of a dominant negative MAPK mutant, ERK192A, resulted in a decrease of both SRE- and SIE dependent activation of c-fos promoter by GM-CSF, suggesting that STAT1/3 are regulated not only by tyrosine kinases, but also partially by MAPK
Nishiya et al., FEBS Lett 1997 (Glioma) : Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-gamma induced MAPK activation that is mediated by p21ras ... Recent studies have reported that MAPK is responsible for serine phosphorylation of Stat1 which is required for Stat1 's DNA binding and maximal transcriptional activity