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EPO — STAT1
Text-mined interactions from Literome
Kirito et al., Blood 2002
(Leukemia) :
To clarify the mechanism by which
EPO activates
Stat1 and Stat3 via the EPO receptor (EPOR), a series of chimeric receptors was constructed bearing the extracellular domain of the granulocyte colony stimulating factor receptor linked to the transmembrane domain of EPOR and the full length or several mutants of the cytoplasmic domain of EPOR, and these chimeric receptor complementary DNAs were introduced into UT-7/EPO cells
Kirito et al., Int J Hematol 2002
(Leukemia, Erythroblastic, Acute) :
Previously, we demonstrated that
Stat1 and Stat3 are
activated by
erythropoietin (EPO) in a human EPO dependent erythroleukemia cell line UT-7/EPO
Kortylewski et al., J Invest Dermatol 2004
(Melanoma...) :
Erythropoietin stimulation of a chimeric receptor
led to a concentration dependent
STAT1 activation and concomitant growth arrest when it contained the STAT recruitment motif Y440 of the interferon-gamma receptor 1
Arcasoy et al., Biochim Biophys Acta 2005
(Polycythemia) :
The positive effect of either Y285 or Y344 on cellular proliferation was associated with
Epo induced tyrosine phosphorylation of
Stat1
Nishigaki et al., J Virol 2006
(Cell Transformation, Viral) :
Erythroblast transformation by the friend spleen focus forming virus is associated with a block in
erythropoietin induced
STAT1 phosphorylation and DNA binding and correlates with high expression of the hematopoietic phosphatase SHP-1
Penta et al., J Biol Chem 1995
:
Erythropoietin induces the tyrosine phosphorylation, nuclear translocation, and DNA binding of
STAT1 and STAT5 in erythroid cells ...
STAT1 and STAT5 DNA binding activities were also activated in an
EPO dependent manner ... The magnitude of the EPO dependent STAT5 activation appeared to be greater than the
EPO dependent
activation of
STAT1
Kirito et al., J Biol Chem 1997
:
This indicates that IL-3, GM-CSF, and
EPO commonly
activated Stat1alpha , Stat3, and Stat5 proteins in UT-7