Gene interactions and pathways from curated databases and text-mining

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SIRT1 — SREBF1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

You et al., Am J Physiol Gastrointest Liver Physiol 2008 (Disease Models, Animal...) : The present study tests the hypothesis that activation of SREBP-1 by ethanol may be mediated by mammalian sirtuin 1 (SIRT1) , a NAD ( + ) -dependent class III protein deacetylase ... Our results indicate an essential role for SIRT1 in mediating the effects of ethanol on SREBP-1 and hepatic lipid metabolism, as well as the development of alcoholic fatty liver
Defour et al., PloS one 2012 : Previous studies indicate that SIRT1 can regulate the expression and function of SREBP-1c in liver ... In the present study, we determined whether SIRT1 regulates SREBP-1c expression in skeletal muscle ... This suggests a possible mechanism by which the regulation of SREBP-1c gene expression by SIRT1 may require the deacetylation of LXR transcription factors
Jin et al., Toxicol Appl Pharmacol 2013 : We found that the ability of resveratrol to repress T0901317 induced SREBP-1c expression was not dependent on AMPK and Sirt1