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SIRT1 — SREBF1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
You et al., Am J Physiol Gastrointest Liver Physiol 2008
(Disease Models, Animal...) :
The present study tests the hypothesis that activation of
SREBP-1 by ethanol may be
mediated by mammalian
sirtuin 1 (SIRT1) , a NAD ( + ) -dependent class III protein deacetylase ... Our results indicate an essential
role for
SIRT1 in mediating the effects of ethanol on
SREBP-1 and hepatic lipid metabolism, as well as the development of alcoholic fatty liver
Defour et al., PloS one 2012
:
Previous studies indicate that
SIRT1 can
regulate the expression and function of
SREBP-1c in liver ... In the present study, we determined whether
SIRT1 regulates
SREBP-1c expression in skeletal muscle ... This suggests a possible mechanism by which the
regulation of
SREBP-1c gene expression by
SIRT1 may require the deacetylation of LXR transcription factors
Jin et al., Toxicol Appl Pharmacol 2013
:
We found that the ability of resveratrol to repress T0901317 induced
SREBP-1c expression was not
dependent on AMPK and
Sirt1