Gene interactions and pathways from curated databases and text-mining

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RPS6KB1 — SREBF1

Text-mined interactions from Literome

Li et al., Zhonghua Gan Zang Bing Za Zhi 2009 (Liver Cirrhosis) : [ Role of S6K1 in the induction of SREBP1c in mouse hepatic cell by high glucose stimulation ] ... To study the role of S6K1 in the induction of SREBP1c in mouse hepatic cell by high glucose stimulation
Li et al., Biochem Biophys Res Commun 2011 (Fatty Liver...) : Role of S6K1 in regulation of SREBP1c expression in the liver ... Furthermore, depletion of hepatic S6K1 in db/db mice with the use of an adenovirus vector encoding S6K1 shRNA resulted in down-regulation of SREBP1c gene expression in the liver as well as a reduced hepatic triglyceride content and serum triglyceride concentration ... These results thus suggest that S6K1 regulates SREBP1c expression both in cultured hepatocytes and in mouse liver, and that increased hepatic activity of S6K1 contributes at least in part to the pathogenesis of obesity induced hepatic steatosis and hypertriglyceridemia