Gene interactions and pathways from curated databases and text-mining

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MAPK6 — SREBF1

Text-mined interactions from Literome

Nadeau et al., J Biol Chem 2004 (Insulin Resistance...) : We determined the roles of the phosphatidylinositol (PI) 3-kinase and mitogen activated protein ( MAP ) kinase dependent pathways in the effect of mediating insulin on SREBP-1 in L-6 skeletal muscle cells and 3T3 L1 adipocytes, using wortmannin or LY294002 to inhibit the PI 3-kinase pathway, and PD98059 to inhibit the MAP kinase dependent pathway
Gnoni et al., J Cell Physiol 2012 (Carcinoma, Hepatocellular...) : Modulation of SREBP-1 protein level by T ( 3 ) was dependent on MAPK/ERK , PI3K/Akt/mTOR-C1 pathway activation since the MEK inhibitor PD98059 or the PI3K inhibitor LY294002 abolished the stimulatory effect of T ( 3 )
Yan et al., Mol Med 2012 : p38 MAPK was involved in leptin regulation of SREBP-1c expression in cultured HSCs. Leptin induced activation of p38 MAPK led to the decreases in liver X receptor ( LXR ) -a protein level, activity and its binding to the SREBP-1c promoter, which caused the downregulation of SREBP-1c expression