Gene interactions and pathways from curated databases and text-mining

◀ Back to IGF1

IGF1 — SREBF1

Text-mined interactions from Literome

Smith et al., J Invest Dermatol 2008 (Acne Vulgaris...) : IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway ... IGF-1 increases expression of sterol response element binding protein-1 ( SREBP-1 ), a transcription factor that regulates numerous genes involved in lipid biosynthesis ... Using specific inhibitors of each pathway, we found that the increase in expression of SREBP-1 induced by IGF-1 was blocked in the presence of the PI3-K inhibitor but not in the presence of the MAPK/ERK inhibitor
Streicher et al., J Biol Chem 1996 : SREBP-1 mediates activation of the low density lipoprotein receptor promoter by insulin and insulin-like growth factor-I