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AKT1 — SREBF1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SREBF1 → AKT1 (increases, AKT1 Activity, SREBF1 Activity) Porstmann et al., Oncogene 2005*
  Evidence: We also show that Akt leads to the accumulation of nuclear SREBP-1 but not SREBP-2, and that activation of SREBP is required for Akt-induced activation of the FAS promoter.

Text-mined interactions from Literome

Fleischmann et al., Biochem J 2000 : Thus acute activation of PKB is sufficient to induce SREBP1 mRNA accumulation in primary hepatocytes, and might be the major signalling event by which insulin induces SREBP1 gene expression in the liver
Ribaux et al., Biochem J 2003 : The stimulation of gene expression by constitutively active PKB-CaaX and inhibition of the insulin effect by ceramide are compatible with a role for PKB in the insulin dependent induction of GCK and SREBP1
Ono et al., Diabetes 2003 (Fatty Liver...) : In contrast, myr-Akt induced hypertriglyceridemia and hepatic triglyceride accumulation are mediated by both Akt induced SREBP-1 expression and a mechanism involving fatty acid synthesis independent of SREBP-1
Porstmann et al., Oncogene 2005 : Activation of Akt induces synthesis of full-length SREBP-1 and SREBP-2 proteins as well as expression of fatty acid synthase (FAS), the key regulatory enzyme in lipid biosynthesis ... We also show that Akt leads to the accumulation of nuclear SREBP-1 but not SREBP-2, and that activation of SREBP is required for Akt induced activation of the FAS promoter
Rudolph et al., J Mammary Gland Biol Neoplasia 2007 : Stability of SREBP1 may be enhanced by a significant increase in Akt at secretory activation
Yellaturu et al., J Biol Chem 2009 : Furthermore, chemical and molecular inhibitors of the phosphoinositide 3-kinase pathway and its downstream kinase protein kinase B (PKB)/Akt prevented both insulin mediated phosphorylation of nascent SREBP-1c protein and its posttranslational processing ... Furthermore, chemical and molecular inhibitors of the phosphoinositide 3-kinase pathway and its downstream kinase protein kinase B (PKB)/Akt prevented both insulin mediated phosphorylation of nascent SREBP-1c protein and its posttranslational processing
Lewis et al., Adv Enzyme Regul 2011 : It has been shown that nuclear accumulation of the mature form of SREBP1 is induced in response to activation of the serine/threonine kinase Akt , an important effector of the Ras/PI3-kinase signalling pathway
Yecies et al., Cell Metab 2011 : Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1 dependent and independent pathways